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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: Determination of pH-value and acidic reserve
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2012-06-11
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Determination of pH value and acidic reserve according to accepted scientific methods.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Principles of method if other than guideline:
Electrochemic determination of pH
Determination of the acidic reserve via titration
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cerium tetranitrate
EC Number:
236-007-2
EC Name:
Cerium tetranitrate
Cas Number:
13093-17-9
Molecular formula:
Ce.4HNO3
IUPAC Name:
cerium tetranitrate
Test material form:
other: liquid substance in its solvent (i.e. water), as it cannot be obtained without it
Details on test material:
- Name of test material (as cited in study report): Red solution

Test animals

Species:
other: not applicable
Strain:
other: Not applicable
Details on test animals or test system and environmental conditions:
Not applicable

Test system

Type of coverage:
other: Not applicable
Preparation of test site:
other: Not applicable
Vehicle:
not specified
Details on study design:
Purpose:
The higher the buffer capacity of a mixture (solution or slurry) is, the stronger the irritating and corrosive potential is, respectively. The physiological effects of acidic or alkaline solutions are not only determined by the pH value but also by the buffering capacity. That's why it is necessary to determine the alkaline or acid reserve of identified products.

Method:
First, the pH-value of a 10% solution (or slurry) is determined electrochemically at 20°C with a calibrated pH meter (MA 235 Mettler Toledo). This value is recorded.

Determination of the acidic reserve titration:
- For the determination of the acid reserve: the titration volume (in mL) of a 1 mol/L NaOH solution, which is required to achieve a pH of 4 of a 10% solution (or slurry) at 20°C, is recorded.

Calculations:
Titration of the 10% solution/slurry
Acid reserve = titration volume [mL] x 0.4

A product is classified as corrosive if:
pH - 1/12 acid reserve <= -0.5

Results and discussion

In vivo

Results
Remarks on result:
other: The substance is considered to be corrosive
Irritant / corrosive response data:
Corrosive (based on an acidic reserve of 20 and pH of 0.68, the calculation for corrosivity was -0.987 which is lower than -0.5)

Any other information on results incl. tables

A pH value of 0.68 was determined.

Applicant's summary and conclusion

Interpretation of results:
other: corrosive
Conclusions:
The pH value was determined to be 0.68 and the acidic reserve 20. The calculation for corrosivity was -0.987. Therefore a solution containing 10% of cerium tetranitrate was considered to be corrosive.

Corrosive (based on an acidic reserve of 20 and pH of 0.68, the calculation for corrosivity was -0.987 which is lower than -0.5)