Registration Dossier
Registration Dossier
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A mixture of: 4-(2,2,3-trimethylcyclopent-3-en-1-yl)-1-methyl-2-oxabicyclo[2.2.2]octane; 1-(2,2,3-trimethylcyclopent-3-en-1-yl)-5-methyl-6-oxabicyclo[3.2.1]octane; spiro[cyclohex-3-en-1-yl-[(4,5,6,6a-tetrahydro-3,6',6',6'a-tetramethyl)-1,3'(3'aH)-[2H]cyclopenta[b]furan]; spiro[cyclohex-3-en-1-yl-[4,5,6,6a-tetrahydro-4,6',6',6'a-tetramethyl)-1,3'(3'aH)-[2H]cyclopenta[b]]furan]
EC number: 422-040-1 | CAS number: 426218-78-2 CASSIFFIX
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The substance has a half-life of 22 days at pH 7 and 25 °C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 22 d
- at the temperature of:
- 25 °C
Additional information
Hydrolysis of the substance as a function of pH was examined in a study according to OECD TG 111 and in compliance with GLP (Huntingdon, 1995). Test solutions were prepared in stoppered glass flasks (shielded from light) by adding defined nominal concentrations to sterile buffer solutions with pH4, 7, and 9. Sample solutions were taken at various times, the concentration of each sample solution determined by GC, and hydrolysis rates and half-lives determined.
In the preliminary test significant hydrolysis of the test substance was observed at pH 4 (79.8%), pH 7 (79.5% ) and pH 9 (71.9%) after 5 days at 50°C. Therefore higher tier testing were performed. In a first test (Test 1) reaction orders were determined by determining plots of log10 (percent remaining) versus time for Test 1 (50°C). At pH 7 the data points did not fall on a straight line indicating that the hydrolysis reaction was not a pseudo-first order reaction. At pH 4 and 9 the data points were inconclusive. Therefore, for pH 4, 7 and 9, an additional test (Test 2) was performed. In this second test estimates of the half-lives at pH 4, 7 and 9 at 25°C were obtained graphically from plots of log10 (percentage remaining) versus time for Test 2. As the plots were non-linear, the times taken for the test substance concentration to drop to 50% (log10 (percentage remaining) = 1.70) were read directly from the graphs. Based on this approach, the hydrolysis reaction of the test substance at 25°C and pH 4, 7 and 9 occurred with an estimated half-life time of 710 hours (ca. 30 days), 520 hours (ca. 22 days) and 830 hours (ca. 30 days), respectively.
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