Registration Dossier
Registration Dossier
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EC number: 208-760-7 | CAS number: 540-88-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The potential for tertiary butyl acetate to cause dermal sensitization is well understood. In the key study, a Buehler test conducted according to EPA OPP Guideline 81-6, a concentration of 100% tertiary butyl acetate at challenge did not cause a sensitization reaction in ten male guinea pigs previously induced with three separate six-hour epicutaneous, occlusive exposures performed once per week for three weeks.
Justification for classification or non-classification
No evidence of a sensitization response was observed in a guideline dermal sensitization study conducted in guinea pigs. Tertiary butyl acetate is not classified for dermal sensitization according to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.
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