Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 261-222-3 | CAS number: 58353-68-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 93.34 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECHA factors in combination with recent scientific literature
- Overall assessment factor (AF):
- 20.4
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 904 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Start from subacute oral OECD 422 toxicity study; no repeated dose inhalation toxicity study available.
- AF for dose response relationship:
- 1
- Justification:
- Different doses were tested, therefore no additional factor is used.
- AF for differences in duration of exposure:
- 3.4
- Justification:
- Extrapolation from subacute to chronic; see justification attached.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling is already applied in route-to-route extrapolation.
- AF for other interspecies differences:
- 1
- Justification:
- No toxicodynamic differences between species; see justification attached.
- AF for intraspecies differences:
- 2.4
- Justification:
- Refined assessment of population differences; see justification attached.
- AF for the quality of the whole database:
- 1
- Justification:
- Results were based on key Klimisch 1-2 studies (and possible supporting studies).
- AF for remaining uncertainties:
- 2.5
- Justification:
- For remaining uncertainties that would result from the above assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 66.18 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECHA factors in combination with recent scientific literature
- Overall assessment factor (AF):
- 81.6
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 5 400 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Start from subacute oral OECD 422 toxicity study; there was no repeated-dose dermal toxicity study.
- AF for dose response relationship:
- 1
- Justification:
- Different doses were tested, therefore no additional factor is used.
- AF for differences in duration of exposure:
- 3.4
- Justification:
- Extrapolation from subacute to chronic; see justification attached.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default allometric scaling factor for the differences between rats and humans is used.
- AF for other interspecies differences:
- 1
- Justification:
- No toxicodynamic differences between species; see justification attached.
- AF for intraspecies differences:
- 2.4
- Justification:
- Refined assessment of population differences; see justification attached.
- AF for the quality of the whole database:
- 1
- Justification:
- Results were based on key Klimisch 1-2 studies (and possible supporting studies).
- AF for remaining uncertainties:
- 2.5
- Justification:
- For remaining uncertainties that would result from the above assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
DNELs were based on following source information:
- Key data for repeated dose toxicity were available from read-across substance 'Butanoic acid, 4-amino-4-oxo-2(or 3)-sulfo-, N-(C16-C18 (even numbered), C18 unsaturated alkyl), disodium salts' in a combination repeated dose/reproduction and developmental toxicity screening study according to OECD TG 422 (Key study; Hansen, 2013a). The test item was administered orally by gavage as a test item containing 25.5% active ingredient to rats at dose levels of 60, 120 or 300 mg act.ingr./kg bw/day. The application started two weeks before mating on test day one and ended on the day or one day before sacrifice. Day of sacrifice was on test day 37 for the male rats and on lactation day 4 or shortly thereafter for the female rats. One of 10 male and one of 10 female animals both at 120 and 300 mg/kg bw/day died prematurely. At 300 mg/kg bw/day clinical signs in form of salivation, pilo-erection and/or breathing sounds were noted in a few male and female animals for 1 or 2 test days. A statistically significant reduction in body weight was noted temporarily in males dosed at 120 mg/kg bw/day and in both sexes at 300 mg/kg bw/day. Accordingly, food consumption and body weight were statistically significantly reduced in both sexes at 300 mg/kg bw/day. Haematology showed statistically significant changes at 300 mg test item/kg bw/day, including increased MCH and decreased aPTT time (male animals) and increased No. white blood cells and lymphocytes (female animals). Changes in the relative or absolute organ weights of several organs were noted for the male animals dosed at 300 mg test item/kg bw/day, most remarkably for the relative liver weight which increased for almost 20%. The macroscopic and microscopic examinations revealed no test item related changes. NOAEL-levels were as follows: 120 mg/kg bw for paternal/maternal toxicity; 120 mg/kg bw for reproductive toxicity (see Section 7.8.1) and 300 mg/kg bw for developmental toxicity (see Section 7.8.2).
-
Subchronic data were also available from read-across substance 'Butanoic
acid, 4-amino-4-oxosulfo-, N-tallow alkyl derivs., disodium salts' (CAS
No. 68988-69-2) given to albino rats in the diet with test item
containing 35% active ingredient at doses of 0.5, 2 and 8 g act.ingr./kg
bw/day (Tegeris and Underwood, 1976). Due to mortality at 8 g/kg bw/day,
dosing was reduced to 4 g/kg feed/day after 6 weeks. Findings included
decreased body weight gain and food intake at all levels and
gastro-enteritis / acute nephritis within six weeks at 8.00 g/kg/day.
After dose reduction, zonal fatty infiltration in the liver was
observed. At the lowest dose level, decreases in body weight (gain) and
feed intake were minimal (<10%) and were not considered relevant.
Decreased organ weights were observed for heart, liver, kidneys, adrenal
an thyroid weight at the medium and high doses. From the data presented
in this study a NOAEL of 500 mg/kg bw/day could be considered.
- For risk assessment, the lowest NOAEL of 120 mg/kg bw with registered substance tested in the OECD 422 study was selected as dose descriptor for calculation of long term systemic DNELS. This approach was considered conservative, as the NOAEL with read across substance in subchronic study with dietary administration was much higher. Further justification of assessment factors is explained in the DNEL justification document attached to the endpoint summary.
Only systemic long term exposure values for worker and general population were calculated, because no concrete values (like NOAEL, LOAEL etc) are available from acute or irritation studies. The study design of the test conducted assessing the acute and local toxicity does not allow in general the derivation of local or acute DNEL, as most of the tests were, for example, conducted as limit tests due to animal welfare. Therefore a qualitative risk assessment for irritation is performed.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 27.62 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECHA factors in combination with recent scientific literature.
- Overall assessment factor (AF):
- 34
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 939 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Start from subacute oral OECD 422 toxicity study; there was no repeated-dose inhalation toxicity study.
- AF for dose response relationship:
- 1
- Justification:
- Different doses were tested in the various studies, therefore no additional factor is used.
- AF for differences in duration of exposure:
- 3.4
- Justification:
- Extrapolation from subacute to chronic; see justification attached.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling is already applied in route-to-route extrapolation.
- AF for other interspecies differences:
- 1
- Justification:
- No toxicodynamic differences between species; see justification attached.
- AF for intraspecies differences:
- 4
- Justification:
- Refined assessment of population differences; see justification attached.
- AF for the quality of the whole database:
- 1
- Justification:
- Results were based on key Klimisch 1-2 studies (and possible supporting studies).
- AF for remaining uncertainties:
- 2.5
- Justification:
- For remaining uncertainties that would result from the above assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 39.71 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECHA factors in combination with recent scientific literature
- Overall assessment factor (AF):
- 136
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 5 400 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Start from subacute oral OECD 422 toxicity study; there was no repeated-dose dermal toxicity study.
- AF for dose response relationship:
- 1
- Justification:
- Different doses were tested, therefore no additional factor is used.
- AF for differences in duration of exposure:
- 3.4
- Justification:
- Extrapolation from subacute to chronic; see justification attached.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default allometric scaling factor for the differences between rats and humans is used.
- AF for other interspecies differences:
- 1
- Justification:
- No toxicodynamic differences between species; see justification attached.
- AF for intraspecies differences:
- 4
- Justification:
- Refined assessment of population differences; see justification attached.
- AF for the quality of the whole database:
- 1
- Justification:
- Results were based on key Klimisch 1-2 studies (and possible supporting studies).
- AF for remaining uncertainties:
- 2.5
- Justification:
- For remaining uncertainties that would result from the above assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.88 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECHA factors in combination with recent scientific literature
- Overall assessment factor (AF):
- 136
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 120 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Not applicable
- AF for dose response relationship:
- 1
- Justification:
- Different doses were tested, therefore no additional factor is used.
- AF for differences in duration of exposure:
- 3.4
- Justification:
- Extrapolation from subacute to chronic; see justification attached.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default allometric scaling factor for the differences between rats and humans is used.
- AF for other interspecies differences:
- 1
- Justification:
- No toxicodynamic differences between species; see justification attached.
- AF for intraspecies differences:
- 4
- Justification:
- Refined assessment of population differences; see justification attached.
- AF for the quality of the whole database:
- 1
- Justification:
- Results were based on key Klimisch 1-2 studies (and possible supporting studies).
- AF for remaining uncertainties:
- 2.5
- Justification:
- For remaining uncertainties that would result from the above assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
DNELs were based on following source information:
-Key data for repeated dose toxicity were available from read-across substance 'Butanoic acid, 4-amino-4-oxo-2(or 3)-sulfo-, N-(C16-C18 (even numbered), C18 unsaturated alkyl), disodium salts' in a combination repeated dose/reproduction and developmental toxicity screening study according to OECD TG 422 (Key study; Hansen, 2013a).The test item was administered orally by gavage as a test item containing 25.5% active ingredient to rats at dose levels of 60, 120 or 300 mg act.ingr./kg bw/day. The application started two weeks before mating on test day one and ended on the day or one day before sacrifice. Day of sacrifice was on test day 37 for the male rats and on lactation day 4 or shortly thereafter for the female rats. One of 10 male and one of 10 female animals both at 120 and 300 mg/kg bw/day died prematurely. At 300 mg/kg bw/day clinical signs in form of salivation, pilo-erection and/or breathing sounds were noted in a few male and female animals for 1 or 2 test days. A statistically significant reduction in body weight was noted temporarily in males dosed at 120 mg/kg bw/day and in both sexes at 300 mg/kg bw/day. Accordingly, food consumption and body weight were statistically significantly reduced in both sexes at 300 mg/kg bw/day. Haematology showed statistically significant changes at 300 mg test item/kg bw/day, including increased MCH and decreased aPTT time (male animals) and increased No. white blood cells and lymphocytes (female animals). Changes in the relative or absolute organ weights of several organs were noted for the male animals dosed at 300 mg test item/kg bw/day, most remarkably for the relative liver weight which increased for almost 20%. The macroscopic and microscopic examinations revealed no test item related changes. NOAEL-levels were as follows: 120 mg/kg bw for paternal/maternal toxicity; 120 mg/kg bw for reproductive toxicity (see Section 7.8.1) and 300 mg/kg bw for developmental toxicity (see Section 7.8.2
-
Subchronic data were also available from read-across substance 'Butanoic
acid, 4-amino-4-oxosulfo-, N-tallow alkyl derivs., disodium salts' (CAS
No. 68988-69-2) given to albino rats in the diet with test item
containing 35% active ingredient at doses of 0.5, 2 and 8 g act.ingr./kg
bw/day (Tegeris and Underwood, 1976). Due to mortality at 8 g/kg bw/day,
dosing was reduced to 4 g/kg feed/day after 6 weeks. Findings included
decreased body weight gain and food intake at all levels and
gastro-enteritis / acute nephritis within six weeks at 8.00 g/kg/day.
After dose reduction, zonal fatty infiltration in the liver was
observed. At the lowest dose level, decreases in body weight (gain) and
feed intake were minimal (<10%) and were not considered relevant.
Decreased organ weights were observed for heart, liver, kidneys, adrenal
an thyroid weight at the medium and high doses. From the data presented
in this study a NOAEL of 500 mg/kg bw/day could be considered.
- For risk assessment, the lowest NOAEL of 120 mg/kg bw with registered substance tested in the OECD 422 study was selected as dose descriptor for calculation of long term systemic DNELS. This approach was considered conservative, as the NOAEL with read across substance in subchronic study with dietary administration was much higher. Further justification of assessment factors is explained in the DNEL justification document attached to the endpoint summary.
Only systemic long term exposure values for worker and general population were calculated, because no concrete values (like NOAEL, LOAEL etc) are available from acute or irritation studies. The study design of the test conducted assessing the acute and local toxicity does not allow in general the derivation of local or acute DNEL, as most of the tests were, for example, conducted as limit tests due to animal welfare. Therefore a qualitative risk assessment for irritation is performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.