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EC number: 940-411-0 | CAS number: 1353749-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect at the time of study conduct.
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- 2-amino-3-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide hydrochloride
- EC Number:
- 940-411-0
- Cas Number:
- 1353749-74-2
- Molecular formula:
- C10H14ClN3O5
- IUPAC Name:
- 2-amino-3-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide hydrochloride
- Details on test material:
- - Purity: 99.9%
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 16.3 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: range of 16.0 to 16.7 g/L
Any other information on results incl. tables
Solubility Table.
Results |
Sample 1 |
Sample 2 |
Sample 3 |
Solubility (g/L) |
16.7 |
16.0 |
16.1 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
Very soluble (average solubility was 16.3 g/L at 20°C) - Executive summary:
The test substance and purified water (10 mL) were weighed upon an analytical balance and added to a 20 mL glass vial. The vial was equipped with a magnetic stirring bar, was then sealed and put in a tempered block set at 20°C. Three replicate samples were prepared containing 500.3, 500.2 and 500.1 mg of the test substance. The blending of the test substance and water resulted in white slurries which turned into clear, light yellow solutions after a couple of minutes of stirring. After approximately one hour new precipitates had formed leaving behind pearly white slurries. The samples were left to stir overnight at 20°C. After that, stirring was stopped and the solids were allowed to settle. From each supernatant was then removed a 5 mL sample using a syringe. The supernatants were filtered via 0.45 µm syringe filters and were collected in pre-weighed round bottomed flasks. The weight of each supernatant was registered. Evaporation resulted in yellow films of solid in the round bottomed flasks (45°C in evaporator water bath). The solids were dried further at 50°C under vacuum overnight and were then weighed. The solubility was then determined.
Average solubility was calculated to be 16.3 g/L (16300 mg/L).
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