4,6-dichloropyrimidine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1996

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

yes

Remarks:

minor deviations e.g. dose level

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4,6-dichloropyrimidine

EC Number:

214-770-2

EC Name:

4,6-dichloropyrimidine

Cas Number:

1193-21-1

Molecular formula:

C4H2Cl2N2

IUPAC Name:

4,6-dichloropyrimidine

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

polyethylene glycol

Doses:

2000 mg/kg/b.w.
200 mg/kg/b.w.

No. of animals per sex per dose:

3 females 2000 mg/kg/b.w.
3 females 200 mg/kg/b.w.
3 males 200 mg/kg/b.w.

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 200 mg/kg bw

Based on:

test mat.

Remarks on result:

other: The LD50 value for male and female rats is greater than 200 mg/kg and was not exactly determined.

Any other information on results incl. tables

Animals employed as well as mortality

dose (mg/kg b.w)       sex       number of animals*       time of deaths       mortality %

200                            m            0/3                                                         0

200                            f             0/3                                                         0

2000                          f              2/3                            3 hours                  67   

* number of animals dying/number of animals employed

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 value for male and female rats is greater than 200 mg/kg and was not exactly determined.
Based on the investigations, the test substance has to be regarded as harmful if swallowed.

Executive summary:

Toxicological investigations in male and female rats were conducted after single oral administration of 4,6 -dichloropyrimidine. The LD50 was greater than 200 mg for the male and female rats.

After administration of 2000 mg/kg body weight the following clinical signs were observed in female rats: dazed condition and apathy. Two of three animals died.

After a single doese of 200 mg/kg no signs were observed in male rats, females showed piloerection up to 8 hours after application.

Body weight development was not significantly affected in both sexes after 200 mg/kg.

At necroscopy of the two intercurrent deaths females (2000 mg/kg) showed the following gross pathological findings: strong reddening of the muscosa in stomach and small intestine, liver mottled.

None of the animals sacrified at the end of study showed any noticeable gross pathological findings.