Registration Dossier
Registration Dossier
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EC number: 261-673-6 | CAS number: 59231-34-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report not available and documentation insufficient for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Decyl and Isodecyl Oleates. Cosmetic Ingredient Review.
- Author:
- Anonymous
- Year:
- 1 982
- Bibliographic source:
- J Am Coll Toxicol, 1982; 1(2):85-95
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- The undiluted test substance was applied to the skin of volunteers and covered with an occlusive patch for 24 hours. The skin irritation was assessed after patch removal.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isodecyl oleate
- EC Number:
- 261-673-6
- EC Name:
- Isodecyl oleate
- Cas Number:
- 59231-34-4
- Molecular formula:
- C28H54O2
- IUPAC Name:
- 2-methylnonyl (9E)-octadec-9-enoate
- Details on test material:
- - Name of test material (as cited in study report): isodecyl oleate
- Analytical purity: no data
Constituent 1
Method
- Type of population:
- not specified
- Subjects:
- - Number of subjects exposed: 19
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Details on exposure:
- The undiluted test substance was applied to the skin of volunteers and covered with an occlusive patch for 24 hours.
- Examinations:
- - Other: the skin irritation was assessed after patch removal
Results and discussion
- Results of examinations:
- - Other: no skin irritation effects were observed
Applicant's summary and conclusion
- Conclusions:
- The test substance did not cause skin irritation after exposure under occlusive conditions.
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