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Diss Factsheets
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EC number: 939-511-7 | CAS number: 1064698-37-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted before adoption of GLP but well documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- FC-43
- IUPAC Name:
- FC-43
- Details on test material:
- - Name of test material (as cited in study report): FC-43
- Lot/batch no.:137
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Both intact, shaved skin and abraded shaved skin was tested.
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- Scoring occured at patch removal and again after 72 hours.
- Details on study design:
- TEST SITE
- Area of exposure: Back
- Type of wrap if used: Saran wrap
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24
SCORING SYSTEM:Erythema and edema 0-4
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: Observations at 24 and 72 hours
- Score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Irritation scores of zero were seen at each observation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The results of the investigation shed that FC-43 produces no skin irritation. Scores of zero were obtained at both the 24-hour and 72-hour scoring intervals.
- Executive summary:
A primary skin irritation study was performed with the test article using six New Zealand albino rabbits. The backs of the rabbits were clipped free of hair using electric clippers on the day prior to the test. Four test sites, two intact and two abraded, were utilized on the back of each rabbit. The abraded sites were prepared by making minor skin incisions through the stratum corneum, but were not deep enough to disturb the derma. Volumes of 0.5 mL of undiluted test article were introduced under two-inch square gauze patches taped to the exposure sites. The trunk of each animal was then wrapped with Saran Wrap secured with masking tape. After 24 hours of exposure the wrappings were removed and the skin sites were scored for erythema and edema on scales from 0 to 4 for each. The sites were then washed to remove any residual test article. Scoring was repeated at 72 hours an a combined average for both intact and abraded skin over both time periods was calculated. The results of the study showed that the test article produced no skin irritation. Scores of zero were obtained at 24 and 72 hours of observation.
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