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EC number: 266-577-8 | CAS number: 67109-27-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10/06/2014 to 10/08/2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Lot. 119-35
- Appearance: Red powder - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.33
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Type:
- Pow
- Partition coefficient:
- ca. 21.3
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Conclusions:
- The partition coefficent n-octanol/water (Log Pow) of FAT 20028/E at 20 °C was determined to 1.33.
- Executive summary:
The study was carried out to determine the partition coefficient n-octanol / water of FAT 20028/E according to the EU method A.8 and OECD guideline 107 using flask method. According to this preliminary test the solubility of the test item in n-octanol is about 10 g/l (without correction of the purity). In conclusin, based on the study results, the partition coefficent n-octanol/water of the test item at 20 °C was determined to Pow = 21.3 and Log Pow = 1.33.
Reference
Determination of the solubility in the n-Octanol phase: Flask Method
Experiment |
A |
B |
C |
D(blank) |
Amount of test item (mg) |
1000 |
1000 |
1000 |
-- |
Stirring time at 30°C (h) |
24 |
48 |
72 |
72 |
Aliquot of the flasks (ml) |
0.025/10 |
0.025/10 |
0.025/10 |
0.025/10 |
End volume (ml) |
10 |
10 |
10 |
10 |
Measured concentration (μg/ml) |
32.5 |
32.1 |
32.7 |
-- |
Solubility (g/l) |
13.0 |
13.0 |
13.1 |
-- |
The values of the measured concentrations of the test item in n-octanol is 13.1 g/l.
Determination of the partition coefficient
Experiment Ratio octanol/water |
A Ratio 1:1 |
B Ratio 1:2 |
C Ratio 2:1 |
Stock solution in mg/100 ml |
7.5 |
7.5 |
7.5 |
Stock solution in ml |
4 |
4 |
8 |
Flask concentration in μg |
300 |
300 |
600 |
Water volume in ml |
4 |
8 |
4 |
Measured concentration n-octanol phase (μg) |
299 |
282 |
565 |
Measured concentration water phase (μg) |
14.7 |
14.8 |
23.2 |
POW |
20.3 |
19.1 |
24.4 |
Log POW |
1.31 |
1.28 |
1.39 |
Description of key information
A study was carried out to determine the partition coefficient n-octanol / water of FAT 20028/E according to the EU method A.8 and OECD guideline 107 using flask method. According to this preliminary test the solubility of the test item in n-octanol is about 10 g/l (without correction of the purity). In conclusion, the partition coefficent n-octanol/water of the test item at 20 °C was determined to Pow = 21.3 and Log Pow = 1.33.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.33
- at the temperature of:
- 20 °C
Additional information
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