Registration Dossier
Registration Dossier
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EC number: 273-050-6 | CAS number: 68936-98-1 The complex combination of hydrocarbons produced by the distillation of products from cumene manufacturing process. It consists primarily of diisopropylbenzene with various small amounts of C4 substituted benzenes and heavier non-aromatic hydrocarbons.
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Harlan CCR, Rossdorf
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Benzene, (1-methylethyl)-, distn. residues
- EC Number:
- 273-050-6
- EC Name:
- Benzene, (1-methylethyl)-, distn. residues
- Cas Number:
- 68936-98-1
- Molecular formula:
- Cannot be given for UVCB
- IUPAC Name:
- (prop-1-en-2-yl)benzene; (propan-2-yl)benzene; 1,2,3-tris(propan-2-yl)benzene; 1,2,4-tris(propan-2-yl)benzene; 1,2-bis(propan-2-yl)benzene; 1,3,5-tris(propan-2-yl)benzene; 1,3-bis(propan-2-yl)benzene; 1,4-bis(propan-2-yl)benzene; 1-methyl-4-(propan-2-yl)benzene
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan laboratories BV, Ad Horst/The netherlands
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 19-21 g
- Acclimation period:5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-2
- Humidity (%): 45-65
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0, 20, 50, 100%
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- EC3: 8.5%
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: 20%: 2.82, 50%: 4.24, and 100%: 3.42 EC3: 23.8% (w/v)
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Based on the EC3 value of 23.8% Cumene bottoms was found to be a skin sensitizer.
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