Registration Dossier
Registration Dossier
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EC number: 854-058-4 | CAS number: 58625-89-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
For the substance an EC50 of 8.0 mg/l for Daphnia is derived, based on ECOSAR prediction using the determined log Kow of 3.1.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 8 mg/L
Additional information
The acute Daphnia EC50 for the ester Ethyl 2-methyl-3-pentenoate is predicted to be 8.0 mg/l based on the ECOSAR SAR for esters using a measured log Kow of 3.1, a molecular weight of 142 and the equation: Log 48h-LC50 (mmol/L) = -0.6305 (log Kow) + 0.7049. The LC50 in ECOSAR is considered equivalent to the EC50 as defined in OECD TG 202.
Ethyl 2-methyl-3-pentenoate is in the applicability domain of the ECOSAR prediction because: a) the substance is an ester presenting the toxicity solely by its bioavailability; b) its log Kow is 3.1 (=< 5); c) its MW is 142 (< 1000); and; d) the toxicity predicted is below its water solubility of 613 mg/l.
The measured and predicted log Kows of the substance are 3.1 and 2.54. In view of the difference being > 0.5, the measured log Kow of 3.1 is used presenting a conservative value (a lower EC50).
In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute Daphnia toxicity on esters (see attached report). The adequate and reliable documentation presented, further supports this prediction.
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