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EC number: 406-810-4 | CAS number: 40649-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The hydrolysis of the test substance was determined according to OECD 111. Under the given conditions the DT50 is more than one year (reference 5.1.2-1).
Biodegradation:
The degradation rate of the test material was 1.2% after 28 days and did not reach 60 % within the 10-day window and after 28 days of incubation. Therefore the test substance cannot be described as ready biodegradable under the test conditions (reference 5.2.1-1).
Additional information
Hydrolysis:
The hydrolysis of the test substance was determined according to OECD TG 111. The test substance (400 mg/L) and 50 mL of the buffer solution (pH 4, 7 and 9) were put in brown iodine determination flasks. The three replicates were analysed with GC after 2.4 h and 5 days. Additionally the hydrolysis of the reference substance acetylsalicylic acid was determined the same way and analysed with HPLC. Mean values and standard deviation were calculated with a programmed pocket calculator (TI SR-51-11). The hydrolysis of the test substance was below 50% independent of the pH. The reference substance acetylsalicylic acid is totally hydrolysed after 5 days at pH 7 and 9. After 5 days at pH 4 0.1% of the start concentration was measured. After 2.4h at pH 4 72.73 % of the start concentration were measured, at pH 7 50.93% and at pH 9 45.60%. The test substance is an arylketone, theoretical no hydrolisation is possible. The test results after 2.4 h exposure in aqueous medium in a decrease in concentration of approx. 10-20%. Since the values are again higher after 5 days it can be assumed that this decline is not due to degradation, but an artifact of the method could be responsible. As the water solubility of the substance is not good, the determination of the concentration is only possible with a relatively large error. The results lead to a DT50 of the test substance in the environment of more than one year (reference 5.1.2-1).
Biodegradation:
The test item was investigated for its ready
biodegradability in a Closed Bottle Test over a period of 28 days
according to OECD TG 301D. The biodegradation was followed by the oxygen
depletion of the microorganisms during exposure. As a reference
substance sodium-n-dodecylsulfate was tested simultaneously under the
same conditions as the test item, and functioned as a procedure control.
The oxygen depletion was measured after 5, 15, and 28 days by means of
an oxygen electrode. Control- and blank-series without the test
substance were run simultaneously and the effectiveness of the inoculum
was confirmed (in a third series with sodium-n-dodecylsulfate as
reference substance) and found to be 72.8 % after 28 days under the
conditions of the test. The value of chemical oxygen demand (TOD) of the
test substance was calculated to be 2.86 mg 02/mg active substance. For
the test substance, a biodegradability of about 1.2 % (after 28 days)
was found. Therefore the test substance cannot be described as ready
biodegradable under the test conditions. Moreover it should be tested,
whether the test substance exerts an inhibiting effect on biological
degradation processes. As a result it was established that the test
substance has no inhibiting effect on the biological degradation of the
reference substance (reference 5 .2.1-1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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