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Diss Factsheets
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EC number: 236-885-7 | CAS number: 13532-94-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 02, 2018 to March 02, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- Incubation temperature ranged from 16.8 to 20.5 °C
- Principles of method if other than guideline:
- All bottles should be incubated at 22 ± 2ºC, however, the incubation temperature ranged from 16.8 to 20.5 °C on day 6. The temperature on all other days was within an acceptable limit. It is the opinion of the study director that the inoculum viability, and ultimate outcome of the study, was not significantly affected by this temperature deviation given that the reference material achieved the guideline validation criteria and the test item continued to steadily degrade.
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Secondary effluent from a sewage treatment work
- Details on inoculum:
- - Source of inoculum/activated sludge: Cambridge STW, Cowley Road, Cambridge
- Collection date: 01 February 2018
- Pretreatment: Filtered
- Concentration of sludge: 1ml/l
- Water filtered: Yes
- Type and size of filter used, if any: Whatman No. 54 - Duration of test (contact time):
- 28 d
- Initial conc.:
- 2.88 mg/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The dilution water was prepared by adding secondary effluent inoculumn and mineral nutrient stock solutions to deionised water. The buffer stock consisted of phosphate, magnesium, calcium, and iron (III) chloride. All buffer solutions were added at 1 ml/L to a total volume of 20 L of deionised water and secondary effluent was added at 1 ml/L to a total volume of 20 L of deionised water.
- Test temperature: 16.8 - 20.5 °C
- Aeration of dilution water: Aerated strongly for 25 minutes and left to stand for 23 hours and 26 minutes before adding the inoculum.
- Continuous darkness: Yes
TEST SYSTEM
- Culturing apparatus: BOD bottles (250 ml)
- Number of culture flasks/concentration: 11 flasks with test concentration of 2.88 mg/l
- Measuring equipment: Dissolved oxygen meter
- Test performed in closed vessels due to significant volatility of test substance: Test vessel sealed with glass stoper
SAMPLING
- Sampling frequency: 0, 7, 14, 21, 28 days
- Sample storage before analysis: in the dark at 16.8-20.5C
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: No
- Toxicity control: No - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 21
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 61
- Sampling time:
- 14 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 66
- Sampling time:
- 21 d
- Details on results:
- A ThOD of 2232 mgO2/g 2-butoxyethyl methacrylate was calculated using structural information.
- Results with reference substance:
- ThOD of sodium acetate 780 mgO2/g. Average degradation on day 7, 14, 21, and 28 of 66, 68, 73, and 57 % respectively.
- Validity criteria fulfilled:
- yes
- Remarks:
- At the point where test degradation had achieved >60% degradation (day 21), all validity criteria were met.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- 2-Butoxyethyl methacrylate gave a positive result (60% degradation relative to the ThOD/COD value), achieving a maximum of 66% degradation at day 21, in a 28-day experiment to determine the capacity of the registered substance to biodegrade in water.
- Executive summary:
A 28-day experiment was undertaken to determine the ready biodegradability potential of 2-butoxyethyl methacrylate in freshwater conditions according to Good Laboratory Practice (GLP) and OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test). Degradation is defined as the ratio of the biochemical oxygen demand (BOD) within 28 days to either the theoretical oxygen demand (ThOD) or the chemical oxygen demand (COD). A small deviation occurred in temperature on day 6 (16.8 to 20.5 °C), however, it was concluded that this did not impact the overall biodegradation outcome given that the inoculum viability was not significantly affected. A secondary effluent inoculum from a sewage treatment plant was prepared along with a mineral medium, the latter of which consisted of the effluent inoculum, mineral nutrient stock solutions, and deionised water. A final test concentration of 2.88 mg/L for the test substance was obtained via a dilution series. An inoculated mineral medium only control and a reference substance treatment (5.01 mg/L) were also prepared. Initial dissolved oxygen (DO) concentrations were measured using a dissolved oxygen meter.
All validity criteria in the study were satisfied between day 0 and 21. At day 21 the reference substance had achieved a degradation of 73 %, however, blank DO losses reached 2.06mg/l by day 28. The guideline requires that the reference material degrades by at least 60% of its ThOD, and that the blank dissolved oxygen loss does not exceed 1.5mg/l after 28 days. Experimental data collected past day 21 should subsequently be disregarded.
As the degradation of 2-butoxyethyl methacrylate achieved on day 21 was 66 %, which is >60 % (CLP Regulation (EC) No. 1272/2008), and this time point was within the acceptability limits of all validity criteria, 2-butoxyethyl methacrylate can ultimately be regarded as being readily biodegradable under the conditions of the study.
Reference
Description of key information
In a 28-day experiment to assess the capacity of 2-butoxyethyl methacrylate to biodegrade in water (OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)), the registered substance was determined to be readily biodegradable. This conclusion was based on a biodegradation result of >60 % (66 %) on day 21, which indicate that the substance is ready biodegrdable under the test conditions. The result obtained for day 28 should be disregarded given that the blank dissolved oxygen reading exceeded the threshold outlined in the guideline, invalidating the data for this sampling point.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.