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EC number: 213-063-6 | CAS number: 921-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-03-04 to 2002-09-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,3-trichloroacetone
- EC Number:
- 213-063-6
- EC Name:
- 1,1,3-trichloroacetone
- Cas Number:
- 921-03-9
- Molecular formula:
- C3H3Cl3O
- IUPAC Name:
- 1,1,3-trichloropropan-2-one
- Details on test material:
- - Name of test material (as cited in study report): 1,1,3-Trichloraceton
- Substance type: Industrial chemical
- Physical state: liquid
- Purity test date: not given in report
- Lot/batch No.: 1TC112013
- Expiration date of the lot/batch: 2002-12-31
- Stability under test conditions: stable
- Storage condition of test material: room temperature in the dark
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Stability of test material at room temperature: stable
- pH dependance on stability: stable
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): The inoculum used was a secondary effluent from a public waste water treatment plant in Plönm, Germany.
- Storage conditions: kept aerobic
- Storage length: used on day of collection
- Pretreatment: filtered, the first 200 ml beeing discarged
- Initial cell/biomass concentration: 2 X 10e8 bacteria
- Water filtered: yes
- Type and size of filter used, if any:coarse filter - Duration of test (contact time):
- 28
Initial test substance concentration
- Initial conc.:
- 4 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: 0.85 g KH2PO4; 2.85 g K2HPO4 x 3H2O; 3.34 g Na2HPO4 x 2 H2O; 0.05 g NH4Cl,; 2.25 g MgSO4 x 7H2O; 3.64 g CaCl2 x 2 H2O; 0.025 g FeCl3 x g H2O in 100 ml; 1 ml of this solution isadded to 1 l of destilled water
- Test temperature: 19.8 °C
- pH: not given
- pH adjusted: no
- Aeration of dilution water: yes
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 18 bottles
- Method used to create aerobic conditions: aeration
- Measuring equipment: Oxi DIGI 530 with a Tri Oxmatic EO 200 oxygen electrode
- Test performed in closed vessels due to significant volatility of test substance: yes
- Test performed in open system: no
CONTROL AND BLANK SYSTEM
- Inoculum blank: 18 bottles
- Abiotic sterile control: 18 bottles
- Toxicity control: 6 bottles
Results and discussion
- Preliminary study:
- not performed
- Test performance:
- as stated in the Guideline
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 4
- Sampling time:
- 3 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 9.8
- Sampling time:
- 10 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 13.4
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 4
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 5
- Sampling time:
- 28 d
- Details on results:
- not available
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- Test substance is not readily biodegradable under conditions used.
- Executive summary:
1,1,3 -Trichlorocetone was examined for its redily biodegradability in a 28 days closed bottle test according to OECD Guideline 301 D at a concentration of 4 mg/l. After 28 days a biodegradation of 5.0 % could be observed. Therefore 1,1,3 -Trichloroacetone was only slightly biodegradable over the 28 day exposure period to a secondary effluent from a domestic sewage treatment plant. The criterion for ready biodegradability (at least 60 % biodegradation within ten days of biodegradation exceeding 10 %) was not reached. On the other hand, the reference compound sodium acetate was biodegraded by an average of 75.3% by exposure day 14 and reached an average biodegradation rate of 84.9% by the end of the 28 day exposure period, this confirming suitability of the secondary effluent. The test substance did not inhibit the inoculum in the toxicity control.
In conclusion, 1,1,3 -Trichloroacetone was not readily biodegradable under the conditions of the Closed Bottle test presently performed.
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