Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-751-3 | CAS number: 866-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No NOAECs were identified neither for rats nor for mice.
LOAEC (local, rat): 0.37 mg/m3 (Tricobalt dicitrate; recalculated value)
LOAEC (local, mouse): 0.37 mg/m3 (Tricobalt dicitrate; recalculated value)
Key value for chemical safety assessment
Justification for classification or non-classification
There are no data available on carcinogenicity of Tricobalt dicitrate. However, there are reliable data available for the structurally related compound cobalt(II)sulfate heptahydrate. Thus, read-across was conducted based on the structural analogue.
DSD: Carcinogenicity category 2; R49
CLP: Carcinogenicity category 1B
Additional information
There are no data available on carcinogenicity of Tricobalt dicitrate. However, there are reliable data available for the structurally related compound cobalt(II)sulfate heptahydrate. Thus, read-across was conducted based on the structural analogue.
Groups of mice and rats were exposed to cobalt(II)sulfate heptahydrate aerosols by inhalation at concentrations of 0, 0.3, 1 and 3 mg/m3 (calculated as anhydrous salt; equivalent to 0.5, 1.6 and 4.8 mg/m3 cobalt hydrogencitrate) 6 hours/day, 5 days/week, for 105 weeks (NTP, 1998).
Mean body weights were increased in all treated female mice and decreased only in the high-dose male mice. Survival was not adversely affected by treatment. The incidences of benign and malignant alveolar/bronchiolar neoplasms were increased in a concentration-dependent manner in male and female mice.
Males: 11/50, 14/50, 19/50, and 28/50 for 0, 0.3, 1, and 3 mg/m3, respectively.
Females: 4/50, 7/50, 13/50, and 18/50 for 0, 0.3, 1 and 3 mg/m3, respectively.
In rats, mean body weights and survival were unaffected by treatment. Female animals exhibited a concentration-related increase in the incidence of benign and malignant alveolar/bronchiolar neoplasms and of benign and malignant pheochromocytomas of the adrenal medulla. The incidences of benign and malignant alveolar/bronchiolar neoplasms were 0/50, 3/49, 15/50 and 15/50 for 0, 0.3, 1 and 3 mg/m3, respectively and of benign and malignant pheochromocytomas were 2/48, 1/49, 4/50, and 10/48 for 0, 0.3, 1, and 3 mg/m3, respectively.
In males, increased incidence of benign and malignant alveolar/bronchiolar neoplasms was observed, but only a marginally increased incidence of pheochromocytomas of the adrenal medulla. The incidences of benign and malignant alveolar/bronchiolar neoplasms were 1/50, 4/50, 4/48, and 7/50 for 0, 0.3, 1, and 3 mg/m3, respectively and of begnin and malignant pheochromocytomas were 15/50, 19/50, 25/49, and 20/50 for 0, 0.3, 1, 3 mg/m3, respectivley.Although many of the alveolar/bronchiolar lesions were morphologically similar to those that arise spontaneously, the lesions in rats, unlike those in mice, were predominantly fibrotic, squamous or mixtures of alveolar/bronchiolar epithelium and squamous or fibrous components. Squamous metaplasia of alveolar/bronchiolar epithelium, which is a common response to pulmonary injury, was observed in number of rats.
The marginally increased incidence of pheochromocytomas in males was considered an uncertain finding because it occurred only in the 1 mg/m3 group and was not supported by increased incidence or severity of hyperplasia. Marginal increases in adrenal medullary tumors may have been exposure related.In summary, cobalt(II)sulfate heptahydrate was found to be carcinogenic in mice and rats when administered by inhalation. There was clear evidence of carcinogenicity in male mice, female mice and female rats, based on increased incidences of lung tumors. In addition, female rats had an increase incidence of pheochromocytoma of the adrenal medulla. Some evidence of carcinogenicity in male rats was observed, based on increased incidences of lung tumors at the highest exposure level. No NOAECs were identified, neither for rats nor for mice. The local LOAECs were determined to be 0.3 mg/m3 (equivalent to 0.37 mg/m3 Tricobalt dicitrate) for mice and rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.