Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-485-6 | CAS number: 96-17-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
2-Methylbutyraldehyde (2-methylbutanal is assessed to be sensitizing based on the common terminal carbonyl group of aldehydes. This reactive group gives reason for a structural alert. Carbonyl groups may form Schiff bases, which then can lead to an immune response. The observation, that many of the tested aliphatic aldehydes were found to be weak or moderate sensitizers, provide evidence for this concept.
The waiving argument is supported by results of a local lymph node assay (Dow 2008) demonstrating a weak sensitizing response of 2-methylbutyraldehyde.
Dow 2008
In a local lymph node assay with 2-methylbutyraldehyde (purity 98.2%), adult female CBA/J mice (6 animals per group) were tested using concentrations of 5, 25, and 100% test substance in vehicle (4:1 acetone/olive oil). Hexyl cinnamic aldehyde (30% in vehicle) was used as positive control material.
There was no effect of treatment on body weight development. Skin irritation, which resolved in all mice by day 6, was only observed on day 3 in mice dosed with 100% test substance (slight to well-defined erythema, 4 and 2 of 6 mice respectively). Increases in lymph cells were only observed in the 100% test group. For this group a SI of 4.4 was determined. EC3 was 70%.
In this study, 2-methylbutyraldehyde is a weak dermal sensitizer (categorized according to the expert ECETOC panel - Technical Report No. 87, 2003) (Dow 2008).
This study is classified as acceptable. It was performed according to OECD test guideline 429 with some restrictions (no individual caging, test substance concentrations were not in consecutive order).
Migrated from Short description of key information:
2-Methylbutyraldehyde is assumed to be skin sensitizing using data waiving (Annex XI, Sect 1.5) based on a grouping of substances and read-across approach.
This waiving argument is supported by results of a local lymph node assay resulting in a weak sensitizing response of 2-methylbutyraldehyde.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.