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Diss Factsheets
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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Intravenous study: 2,4-pentanedione was given to four adult male Fischer 344 rats per dose by single intravenous injection of 4.3, 43, 148.5, and 430 mg/kg bw. Blood was collected at appropriate intervals from a lateral tail vein until 30 or 36 hr post dosing. At 48 hr a cardiac puncture was performed for a final blood sample with all groups. Urine and feces were collected. For airborne collections, room air was drawn through the metabolism cages at approximately 500 mL/min, expired 14CO2 was trapped. After sacrifice the carcass and the following tissues were used for radioactivity measurements: brain, heart, lungs, kidneys, perirenal fat, muscle, spleen, testes, and bone marrow.
- GLP compliance:
- not specified
Test material
- Details on test material:
- Purity: 98%
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C-labelled
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Age: adult
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- physiological saline
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
Dosing solutions were prepared by diluting a appropriate amount of unlabeled 2,4-pentanedione with the 14C-labeled test substance in physiological saline (0.9 %). Target radioactivity was 2-5 mCi. - Duration and frequency of treatment / exposure:
- single intravenous injection
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4.3, 43, 148.5, and 430 mg/kg bw
- No. of animals per sex per dose / concentration:
- 4 males
- Details on dosing and sampling:
- Blood was collected at appropriate intervals from a lateral tail vein until 30 hr (4.3, 43 and 148 .5 mg/kg doses) or 36 hr (430 mg/kg dose group) post dosing. At 48 hr a cardiac puncture was performed for a final blood sample with all groups.
Urine was collected under dry ice freezing conditions at 6, 12, 24, 36 and 48 hr and feces were collected for two 24 hr intervals post dosing.
For airborne collections, room air was drawn through the metabolism cages at approximately 500 mL/min. Expired 14CO2 was trapped at 12, 24 and 48 hr post dosing.
After sacrifice the carcass and the following tissues were used for radioactivity measurements: brain, heart, lungs, kidneys, perirenal fat, muscle, spleen, testes, and bone marrow. Cages were washed with deionized water and methanol (1:1). - Statistics:
- Pharmacokinetic description of plasma 14C disposition following intravenous application was derived using RSTRIP, a pharmacokinetic curve-stripping and fitting program.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- After a single intravenous injection the plasma concentration of 14C-labeled-test substance derived radioactivity declined in a biexponential fashion, with a rapid initial phase followed by a slower terminal phase.
The pharmacokinetic parameters derived were: initial elimination rate constants (k alpha ( hr-1)) of 2.30, 0.97, 1 .32 and 26.02; initial half-life (alpha t1/2 (hr)) of 0.30, 0.71, 0.53 and 0.03; terminal elimination constants (k beta (hr-1)) of 0.045, 0.037, 0.053 and 0.065; terminal half-life (beta t1/2 (hr)) of 15.40, 18.73, 13.08 and 10.66; maximum plasma concentrations (Cmax (µg/g)) of 16.13, 110.8, 499.40 and 4369.46; apparent volumes of distribution (Vd (L/kg)) of 1.79, 2.49, 1.28 and 0.78, mean residence time (MRT (hr)) of 12.8, 12.1, 10.3 and 10.5; and areas under the curve to infinity (AUC (µg hr/g)) of 53.28, 467.09, 2196.61 and 8505.12 for the 4.3, 43, 148.5 and 430 mg/kg bw doses, respectively.
The overall form of the 14C plasma concentration-time curves and derived pharmacokinetic parameters indicated that dose-linear kinetics occurred in the dose range of 4.3-148.5 mg/kg, but not with 433 mg/kg.
- Details on excretion:
- Metabolism of 2,4-pentanedione was quite rapid as the concentration of unmetabolized test substance declined steadily to undetectable after 8 hr in the 430 mg/kg dose group. 14C test substance derived radioactivity was eliminated mainly as 14CO2 and in urine . For the 4.3, 43 and 148.5 mg/kg doses 14CO2 elimination was relatively constant (36.8, 38.8 and 42.3 % in 48 hr samples, respectively) and greater than urinary excretion ( 17.9, 14.3 and 29 .6% in 48 hr samples, respectively). At 430 mg/kg there was a reversal of the excretion pattern, with urine 14C excretion (54.7 %) becoming greater than that for 14CO2 (27.3 %). Excretion in expired volatiles and faeces was small. Radiochromatograms of urine showed free 2,4-pentanedione in the 12 hr sample, together with 7 other metabolites. Most of the urinary radiolable was excreted within the first 24 hr post dosing. Unmetabolized 2,4-pentanedione and 6 of the metabolites decreased or were not detectable in the 24 or 48 hr urine samples, but one peak was still detectable in these. Carcass radioactivity ranged from 5.32 to 9.07%. Total recovery of radioactivity ranged from 69.0 % at the 4.3 mg/kg dose to 95.18% at the 430 mg/kg dose.
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 1st: initial half-life (alpha t1/2 (hr)) of 0.30, 0.71, 0.53 and 0.03
- Toxicokinetic parameters:
- half-life 2nd: terminal half-life ( beta t1/2 (hr)) of 15.40, 18.73, 13.08 and 10.66
- Toxicokinetic parameters:
- Cmax: maximum plasma concentrations (Cmax (µg/g)) of 16.13, 110.8, 499.40 and 4369.46
- Toxicokinetic parameters:
- AUC: areas under the curve to infinity (AUC (µg hr/g)) of 53.28, 467.09, 2196.61 and 8505.12
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Radiochromatograms of urine showed free 2,4-pentanedione in the 12 hr sample, together with 7 other metabolites. Most of the urinary radiolabel was excreted within the first 24 hr post dosing. Unmetabolized 2,4-pentanedione and 6 of the metabolites decreased or were not detectable in the 24 or 48 hr urine samples, but one peak was still detectable in these.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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