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Diss Factsheets
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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2,4-Pentanedione was not irritating to the skin or the eyes of rabbits.
Key value for chemical safety assessment
Additional information
Skin irritation:
In the key study for skin irritation, 0.5 mL undiluted 2,4-pentanedione was applied to the clipped, intact dorsal skin of 6 New Zealand White rabbits (3 males and 3 females) under a gauze patch and was loosely covered with impervious sheeting (BRRC48 -34, 1985). Skin reaction was scored by the method of Draize at 1 hour and 1, 2, 3, 7 and 14 days after removal of the dressing. Mean scores of all 6 animals (24, 48, 72 h) for erythema and edema was 0.8 and 0.4, respectively. After 7 days no erythema and edema reactions have been observed. Slight desquamation was observed in 5/6 animals after 7 days, but was also fully reversible within 14 days.
Eye irritation:
Eye irritation was observed in 6 New Zealand White rabbits, which were instilled 0.1 mL of the test substance (BRRC48 -34, 1985). No washing was performed and the eyes were observed for 7 days. Slight redness or chemosis was observed in the eyes of single animals after 1 and 4 h, respectively. No effects have been observed during the 24, 48, 72 h period or later in any animals.
In conclusion, 2,4 -pentanedione showed no potential for irritation to the skin or to the eyes.
Respiratory irritation:
There exists no standard test method for the assessment of respiratory irritation. Thus, findings for skin/eye irritation, inhalation toxicity and sensitisation are reviewed. Slight reactions on the skin and the eyes were observed in skin/eye irritation studies, especially at early time points. No reliable data are available from sensitization studies. In acute, subacute and subchronic inhalation toxicity studies wetness, inflammation and partly necrosis of the nasal mucosa was reported. No lesions in the lower respiratory tract (trachea and lung) were reported. Thus, based on the data available, respiratory irritation cannot be excluded, but is unlikely to happen in the lower respiratory tract.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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