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EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 November 2005 to 7 December 2005
- Reliability:
- 1 (reliable without restriction)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- EC Number:
- 255-255-2
- EC Name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- Cas Number:
- 41198-08-7
- Molecular formula:
- C11H15BrClO3PS
- IUPAC Name:
- 4-bromo-2-chlorophenyl ethyl (propylsulfanyl)phosphonate
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- Sighting study: 1, 5, 10, 25 and 50% (w/v) LLNA: 1, 2.5, 5% (w/v)
- No. of animals per dose:
- 5 female mice/dose
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 3.4
- Test group / Remarks:
- Test Group III
- Parameter:
- SI
- Value:
- 1.4
- Test group / Remarks:
- Test Group I
- Parameter:
- SI
- Value:
- 1.5
- Test group / Remarks:
- Test Group II
Any other information on results incl. tables
LLNA
All animals appeared normal for the duration of the study. Individual DPM counts are presented below.
The application of the test material at a concentration of 2% (w/v) resulted in an increase in isotope incorporation which was 3.0 times that of the vehicle control. Consequently the test substance was shown to be a potential skin sensitiser.
The positive control produced an acceptable response.
Table 7.4.1 -1: Average disintegrations per minute per mouse
Conc. of test material (% w/v) |
Average disintegrations/minute (dpm) per mouse |
Test : control ratio (SI) |
0 |
565 |
- |
1 |
781 |
1.4 |
2.5 |
870 |
1.5 |
5 |
1899 |
3.4 |
Positive control |
7222 |
12.8 |
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- In conclusion Profenofos Technical (Batch P03) produced a stimulation index >3 in one group of test animals, and is therefore consdiered a skin sensitiser under the conditions of this study.
- Executive summary:
A skin sensitisation study was conducted on 3 groups of 5 female mice to determine if Profenofos Technical (Batch P03) possessed a significant potential to cause skin sensitisation. Test groups were treated with an appropriate dilution (0.5, 1 or 2% w/v) in a 80% acetone:20% olive oil vehicle. Each animal recieved 25 uL to the dorsum of each ear. The animals were treated once daily for three days. Two days post the final application, animals were injected with tritiated methyl-thymidine via the tail vein. Five hours later the animals were sacrificed and the draining auricular lymph nodes removed and prepared for cell suspension and scintillation counting. A vehicle control group of 5 animals was run concurrently. A positive control group of 5 animals was also run concurrently, treated with 90% alpha-hexylcinnamaldehyde in vehicle.
In conclusion Profenofos Technical (Batch P03) produced a stimulation index >3 in one group of test animals, and is therefore consdiered a skin sensitiser under the conditions of this study.
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