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Diss Factsheets
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EC number: 203-500-9 | CAS number: 107-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test done before GLP and Guidelines were established.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single Exposure
A group of ten , male, albino rats weighing between 200 and 500 grams each was used in this study, The rats were placed i n a 70 liter all glass exposure chamber and exposed to a saturated atmosphere of the test material in air for one hour, The material was administered
as an aerosol with particles 3 - 5 microns in diameter. The rate of flow was 23,9 liters per minute at a temperature of 76 °F. The air was passed through a dessicant prior to being passed through the test material.
By differential weighing it was calculated that the rats were subjected to a concentration of 19,700 ppm. This is an average value over the one hour exposure period. - GLP compliance:
- no
Test material
- Reference substance name:
- 3,5-dimethylhex-1-yn-3-ol
- EC Number:
- 203-500-9
- EC Name:
- 3,5-dimethylhex-1-yn-3-ol
- Cas Number:
- 107-54-0
- Molecular formula:
- C8H14O
- IUPAC Name:
- 3,5-dimethylhex-1-yn-3-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Duration of exposure:
- 1 h
- Concentrations:
- 19,700 ppm
- No. of animals per sex per dose:
- 10 male
- Control animals:
- no
Results and discussion
Any other information on results incl. tables
All of the rats survived the one hour exposure period. During the exposure period the rats at first huddled together and their breathing increased in depth. After exposure the rats exhibited complete muscular rigidity with shallow respiration. They remained like this for from one to eight hours and then recovered and were normal throughout the remainder of the observation period. In all rats their eyes appeared normal immediately after removal from the exposure chamber and remained normal throughout the entire observation period. At the end of the 14 day observation period all rats were subjected to gross autopsy examination.
All rats appeared normal on gross examination.
Applicant's summary and conclusion
- Interpretation of results:
- other: non toxic
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- From the results obtained in this study it appears that Surfynol 61 would be considered non toxic.
The one hour LC50 is greater than 19.7 mg/l. This converts to a four hour LC50 greater than 4.9 mg/l - Executive summary:
From the results obtained in this study it appears that Surfynol 61 would be considered non toxic.
The one hour LC50 is greater than 19.7 mg/l. This converts to a four hour LC50 greater than 4.9 mg/l
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