Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-733-8 | CAS number: 5459-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Range-Finding Toxicity Data List VI
- Author:
- Smyth H.F., Carpenter Ch.P., Well C.S., Pozzani U.C., Striegel J.A.,
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal
- Reference Type:
- publication
- Title:
- Chemical burns of the rabbit cornea
- Author:
- Carpenter, Ch.P., Smyth Jr., H.F.
- Year:
- 1 946
- Bibliographic source:
- Am. J. Ophtal.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data on method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexyl(ethyl)amine
- EC Number:
- 226-733-8
- EC Name:
- Cyclohexyl(ethyl)amine
- Cas Number:
- 5459-93-8
- Molecular formula:
- C8H17N
- IUPAC Name:
- N-ethylcyclohexanamine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- other: 180 chemical substances
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Citric acid, Sodium Hydroxide, Saline
- Time after start of exposure: 30-minute interval
SCORING SYSTEM:
- Symtomps visible before fluorescein Staining
- cornea dull 2 points
- cornea Cornea opaque, less than half of area 4 points
- Cornea opaque, more than half of area 6 points (max. 6 points)
- Keratoconus (max. 6 points)
- Iritis, slight internal congestion 1 point
- Iritis, marked internal congestion 2 points (max. 2 points)
- Symptom Visible After Fluorescein Staining(If necrosis is diffuse assign points corresponding to half observed area)
- Necrosis on less than 5% of cornea 1 points
- Necrosis on 5 to 12% 2 points
- Necrosis on 13 to 37% 3 points
- Necrosis on 38 to 62% 4 points
- Necrosis on 63 to 87% 5 points
- Necrosis on 88 to 100% 6 points (max. 6 points)
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0 - <= 9
- Max. score:
- 20
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- other: no data
- Time point:
- 48 h
- Reversibility:
- other: no data
- Remarks on result:
- not determinable because of methodological limitations
- Irritation parameter:
- cornea opacity score
- Basis:
- other: no data
- Time point:
- 72 h
- Reversibility:
- other: no data
- Remarks on result:
- not determinable because of methodological limitations
- Irritation parameter:
- iris score
- Basis:
- other: no data
- Time point:
- 24/48/72 h
- Reversibility:
- other: no data
- Remarks on result:
- other: no data
- Irritation parameter:
- conjunctivae score
- Basis:
- other: no data
- Time point:
- 24/48/72 h
- Reversibility:
- other: no data
- Remarks on result:
- other: no data
- Irritation parameter:
- chemosis score
- Basis:
- other: no data
- Time point:
- 24/48/72 h
- Reversibility:
- other: no data
- Remarks on result:
- other: no data
Any other information on results incl. tables
severe eye irritation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.