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EC number: 469-070-1 | CAS number: 17861-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-06-13 to 2005-07-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Version / remarks:
- 1988
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- 1984
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Due to the low solubility of the test item in test water, adequate amounts of the test item were directly weighed into each test flask. - Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Method of cultivation: The sludge was washed by centrifugation and the supernatant liquid phase was decanted. The solid material was resuspended in tap water and again centrifuged. The latter procedure was repeated twice. An aliquot of the final sludge suspension was weighed, dried and the ratio of wet sludge (g) to its dry weight (g) determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 3 g dry material per litre, were made up with tap water. To this mixture, 50 mL synthetic sewage feed per litre was added, starting two days prior use of the activated sludge. The activated sludge was kept at room temperature under continuous aeration until use. The pH of the activated sludge was 7.3, therefore no adjustment was necessary.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 21 - 22°C
- pH:
- 7.2 at test start
8.0 - 8.2 at test end - Dissolved oxygen:
- 7.8 - 8.1 mg/L at test start
7.4 - 7.9 mg/L at test end - Nominal and measured concentrations:
- Nominal: 10, 32, 100, 320 and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass flasks of approximately 1 litre volume and Karlsruher flasks of 250 mL volume
- Aeration: with compressed air (approximately 0.613 litre per minute)
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
- Sludge concentration (weight of dry solids per volume): 3 g/L - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of respiration rate
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- The following nominal concentrations of the positive control 3,5-Dichlorophenol were tested on the same activated sludge and under identical conditions as the test item: 3,2, 10, and 32 mg/L. In comparison to the controls the respiration rate of the activated sludge was inhibited by 24.3 % at the lowest nominal concentration of 3.2 mg/L. At the nominal concentrations of 10 and 32 mg test item/L, the respiration rate was inhibited by 51.4 and 81.1%, respectively. - Validity criteria fulfilled:
- yes
- Conclusions:
- Based on measured inhibition rates, the 3-hour EC20 and EC50 could not be quantified because up to the highest nominal test concentration of 1000 mg/L less than 20 % inhibition was noted after three hours incubation. Nevertheless, the 3-hour EC20 and EC50 are clearly higher than 1000 mg/L under the present test conditions.
Reference
Table 1: Influence of the test item and the reference item (3,5 -Dichlorophenol, DCP) on oxygen consumption of activated sludge
Flask No. | Treatment | Concentration | Oxygene consumption |
Inhibition | pH- values | Oxygene concentration [mg O2/L] |
||
[mg/L] | [mg O2/L_min] | % | start | end | start | end | ||
1 | Control | --- | 0.350 | --- | 7.2 | 8.2 | 8.1 | 7.9 |
10 | Control | --- | 0.390 | --- | 7.2 | 8.0 | 8.0 | 7.0 |
mean | 0.370 | |||||||
replicate deviation | 10.3 | |||||||
2 | 3,5-DCP | 32 | 0.070 | 81.1 | 7.3 | 8.2 | 8.1 | 8.4 |
3 | 3,5-DCP | 10 | 0.180 | 51.4 | 7.2 | 8.2 | 8.1 | 8.1 |
4 | 3,5-DCP | 3.2 | 0.280 | 24.3 | 7.2 | 8.1 | 8.2 | 7.6 |
5 | Y-14877 | 1000 | 0.340 | 8.1 | 7.2 | 8.0 | 7.8 | 7.6 |
6 | Y-14877 | 320 | 0.370 | 0 | 7.2 | 8.0 | 7.9 | 7.4 |
7 | Y-14877 | 100 | 0.380 | -2.7 | 7.2 | 8.0 | 8.0 | 7.4 |
8 | Y-14877 | 32 | 0.360 | 2.7 | 7.2 | 8.1 | 7.9 | 7.8 |
9 | Y-14877 | 10 | 0.370 | 0 | 7.2 | 8.0 | 8.0 | 7.4 |
Description of key information
Based on the results of a respiration inhibition test, the 3-hour EC20 and EC50 of 3-ethylheptamethyltrisiloxane are concluded to exceed 1000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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