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Diss Factsheets
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EC number: 700-263-8 | CAS number: 89686-69-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: theoretical assessment based on all available info
- Adequacy of study:
- key study
- Study period:
- February 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP assessment report
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
- Reference Type:
- other: study report update
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Objective of study:
- other: toxicokinetic assessment
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Assessment of all available data
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-[2-(oxolan-2-yl)propan-2-yl]oxolane
- EC Number:
- 700-263-8
- Cas Number:
- 89686-69-1
- Molecular formula:
- C11 H20 O2
- IUPAC Name:
- 2-[2-(oxolan-2-yl)propan-2-yl]oxolane
Constituent 1
Test animals
- Species:
- other: none, theoretical assessment
- Strain:
- other: none, theoretical assessment
Administration / exposure
- Route of administration:
- other: oral, dermal and inhalation
- Vehicle:
- other: not applicable
- Details on exposure:
- see assessment
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- For risk assessment purposes, the oral, dermal, and inhalation absorption is set at 100%
Any other information on results incl. tables
The relatively small molecular weight (184.28), the water solubility (7.31 g/L) and the moderate logPow (between 0 and 4) of the substance indicates that uptake from the gastro-intestinal (GI) tract can take place through aqueous pores and by passive diffusion. In general, a substance needs to be dissolved before it can be taken up from the gastro-intestinal tract after oral administration (1). It is therefore likely that Ditetrahydrofurylpropane will be absorbed to a high extent from the GI tract. For risk assessment purposes therefore, the oral absorption of Ditetrahydrofurylpropane is set at 100%. The results of the toxicity studies do not provide reasons to deviate from this proposed oral absorption percentage.
Following absorption, Ditetrahydrofurylpropane being a small water-soluble molecule is expected to distribute widely through the body. Based on its lipophylic character, Ditetrahydrofurylpropane is likely to distribute into cells and the intracellular concentration might be higher than the extracellular concentration. Based on its relatively low molecular weight (184.28), excretion is expected to be predominantly via urine (2).
The water solubility (7.31 g/L) of Ditetrahydrofurylpropane indicates that the substance will dissolve in the mucus lining of the respiratory tract and subsequently be absorbed through aqueous pores (taking the molecular weight <200 into account). The log Pow (> 0) indicates a potential for absorption directly across the respiratory tract epithelium. As it is likely that Ditetrahydrofurylpropane will be absorbed to a high extent after inhalation via the lungs, for risk assessment purposes the inhalation absorption for this substance is set at 100%.
Ditetrahydrofurylpropane being a water soluble liquid (7.31 g/L) has the potential to be dermal absorbed as the surface moisture of the skin will not limit the availability. The logPow of 2.7 favours dermal absorption (values between 2 and 3 are optimal). Furthermore, the moderately skin irritating properties of the substance may result in damage of the skin and thus enhance penetration. Based on these properties, 100% dermal absorption of Ditetrahydrofurylpropane is proposed for risk assessment purposes; being in accordance with the criteria as given in the REACH Guidance on information requirements and chemical safety assessment (3) (10% dermal absorption if MW > 500 and log Po/w < -1; otherwise 100% dermal absorption). The results of the skin sensitisation study confirm that dermal absorption will take place.
Based on the present data, no additional conclusions can be drawn on the distribution, metabolism and excretion of Ditetrahydrofurylpropane after dermal and inhalatory absorption.
Applicant's summary and conclusion
- Conclusions:
- The evaluation of currently available information on Ditetrahydrofurylpropane led to the following toxicokinetic assessment:
- For risk assessment purposes, the oral absorption is set at 100%.
- For risk assessment purposes the inhalation absorption is set at 100%.
- For risk asssessment purposes the dermal absorption is set at 100%.
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