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Diss Factsheets
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EC number: 909-044-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
There no data available on phosphonic ester residue with respect to carcinogenicity.
Based on the available data with dimethylphosphonate, phosphonic ester residue has to be suspected of causing cancer
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Study duration:
- chronic
- Species:
- rat
Justification for classification or non-classification
According to GHS/CLP Regulation 1272 / 2008 section 3.6.3. Classification criteria for mixtures: a mixture will be classified as carcinogen when at least one ingredient has been classified as a Category 1A Category 1 B or Category 2 carcinogen and is present at or above the appropriate generic concentration limit as shown in the respective table.
This requirement is fulfilled for dimethylphosphonate accounting for 11 % in phosphonic ester residue which is classified/labelled by producer with Carc Cat 2 H351= suspected of causing cancer, according to Regulation 1272/2008 (GHS/CLP).
Consequently phosphonic ester residue has to be classified / labelled with category 2 of carcinogenic substances H351= suspected causing cancer
Additional information
There no data available on phosphonic ester residue with respect to carcinogenicity.
Phosphonic ester residue contains monomethyl phosphonate, phosphonic acid, and Dimethylphosphonate, and and pyrophosphoric acid and phosphate which were not further specified.
Monomethylphosphonate and phosphonic acid
There are no data available
Dimethylphosphonate
In a carcinogenicity study (equivalent to OECD guideline 451) dimethyl phosphonate showed evidence of carcinogenicity in male F344 rats and equivocal evidence in female F344 rats. Target organs were lungs and forestomach. No evidence of carcinogenicity was observed in male and female B6C3F1 mice.(US Health and Human Services 1985, UNEP 2006). The substance is classified as Carc Cat 2 (H351= suspected of causing cancer) according to Regulation 1272/2008 (GHS/CLP).
Salt of pyrophosphoric acid and phosphate which are not further specified
there are no data available
Overall, based on the available data with dimethylphosphonate and taking into account GHS/CLP Regulation 1272/2008, phosphonic ester residue has to be suspected of causing cancer.
Justification for selection of carcinogenicity via oral route endpoint:
There no data available on phosphonic ester residue with respect to carcinogenicity.
Based on the available data with dimethylphosphonate phosphonic ester residue has to be suspected of causing cancer
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