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Diss Factsheets
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EC number: 611-210-2 | CAS number: 54914-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with acceptable restrictions (mostly due to reduced reporting in times before GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only 7 days postobservation period, higher doses
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- sodium 2-amino-5-methylbenzenesulfonate
- EC Number:
- 611-210-2
- Cas Number:
- 54914-95-3
- Molecular formula:
- C7 H8 N O3 S Na
- IUPAC Name:
- sodium 2-amino-5-methylbenzenesulfonate
- Details on test material:
- - Name of test material (as cited in study report): Natriumsalz der 4-Toluidin-3-sulfosaeure (sodium salt, pure, solid)
- Analytical purity: no data, pure
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Tuebinger
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 19-32 g
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous solution in Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2% (up to 200 mg/kg bw)/10% (1600 mg/kg bw)/ 40% (>= 6400 mg/kg bw)
MAXIMUM DOSE VOLUME APPLIED: ca. 2.5 mg/kg bw - Doses:
- 200, 1600, 6400 and 10000 mg/kg bw
- No. of animals per sex per dose:
- 5 females in each of the two lower doses, 10 females in each of the two higher doses
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was done only at the beginning of the study for dose calculation. Observation of clinical signs was several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 1/10 animals died in the 10000 mg/kg bw dose
- Mortality:
- 1/10 animals died in the 10000 mg/kg bw dose within 24 hrs after application; no further lethality was observed
- Clinical signs:
- other: - 10000 mg/kg bw: very skittish 3 hrs after application. On the following day one animal showed complete apathy, lateral position before exitus; all other animals recovered completely within 24 hrs - 6400 mg/kg bw: slight apathy on the application day was
- Gross pathology:
- Sacrificed animals: nothing abnormal found
Animal that died: pale kidneys
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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