Registration Dossier
Registration Dossier
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EC number: 202-849-4 | CAS number: 100-41-4
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
because of impurities profile (i.e. presence of benzene), the substance is classified as Carcinogenicity: Carc. Cat. 1; R45 May cause cancer, in accordance with Directive 67/548/EEC and Carcinogen Category 1A; H350: May cause cancer, in accordance with the GHS criteria of Regulation (EC) No 1272/2008.
Additional information
The IARC evaluation of ethylbenzene (IARC, 2000):
· There is inadequate evidence in humans for the carcinogenicity of ethylbenzene.
· There is sufficient evidence in experimental animals for the carcinogenicity of ethylbenzene.
· Overall evaluation: Ethylbenzene is possibly carcinogenic to humans (Group 2B).
Moreover, because of impurities profile (i.e. presence of benzene), the substance is classified as Carcinogenicity: Carc. Cat. 1; R45 May cause cancer, in accordance with Directive 67/548/EEC and Carcinogen Category 1A; H350: May cause cancer, in accordance with the GHS criteria of Regulation (EC) No 1272/2008.
Therefore, no additional testing of ethylbenzene for carcinogenicity is required.
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