Registration Dossier
Registration Dossier
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EC number: 202-180-8 | CAS number: 92-70-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Skin Irritation / Corrosion
- Author:
- SIDS OECD 2004
- Year:
- 2 004
- Bibliographic source:
- SIDS OECD 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- other: polyethylene glycol
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24 hours
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Reversibility:
- no data
- Remarks on result:
- other: no data concerning score
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Moistened 3-hydroxy-2-naphthoic acid was slightly irritating to the skin of rabbits in a test
performed according to OECD TG 404.
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