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EC number: 258-292-2 | CAS number: 53012-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and in accordance with several internationally acknowledged guidelines for the testing of chemicals.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-(2,6-dimethylphenoxy)acetone
- EC Number:
- 258-292-2
- EC Name:
- 1-(2,6-dimethylphenoxy)acetone
- Cas Number:
- 53012-41-2
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 1-(2,6-dimethylphenoxy)propan-2-one
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 2,6-DMPA
- Physical state: liquid
- Analytical purity: 98.8 %
- Purity test date: May 20, 1999
- Lot/batch No.: 34
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge : domestic waste water treatment plant
- Preparation of inoculum for exposure: The activated sludge used for this study was washed by centrifugation and the supernatant liquid phase was decanted. The solid material was resuspened in tap water and again centrifuged. This procedure was
repeated twice. An aliquot of the final sludge suspension was weighed, dried and the ratio of the wet sludge
to its dry weight to determined. Based on this ratio, calculated aliquots of washed slidge suspension ,
corresponding to 1.5 g dry material per litre were mixed with test water and then aerated until use.
- Water filtered: no - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- ca. 25 other: mg
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Solubilising agent (type and concentration if used): no
- Test temperature: 22 °C
- pH: 7.6 at test start
- Light Conditions: darkness
- Suspended solids concentration: 30 mg/L
TEST SYSTEM
- Culturing apparatus: Manometric Test System with test flakes of a volume of 500 mL
- Number of culture flasks/concentration: 2
- Details of trap for CO2 and volatile organics if used: aqueous solution ( 45 % ) of potassium hydroxide
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes
- Toxicity control: yes
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 49 - 55
- Sampling time:
- 28 d
- Details on results:
- The percentage biodegradation did not exceed 60 % within the 10-day window. The test substance can therefore not considered to be ready biodegradable.
BOD5 / COD results
- Results with reference substance:
- The reference compound Aniline was sufficiently degraded to 85 % after 14 days, and to 110% after 28 days of incubation. The percentage biodegradation of the reference compound confirms the suitability of the used activated sludge inoculum.
Any other information on results incl. tables
Biodegradation in the Toxicity Control:
In the toxicity control containing both, the test substance and the reference compound Aniline, 42 % biodegradation was noted within 14 days and 49 % biodegradation was determined after 28 days of incubation.
According to the test guidelines the test substance can be assumed to be not inhibitory on the activated sludge micro organisms because degradation was > 25 % within 14 days.
Abiotic Control:
The oxygen demand in the abiotic control was nearly the same as in the two control flasks
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: The test substance can therefore not considered to be ready biodegradable.
- Conclusions:
- The percentage biodegradation did not exceed 60 % within the 10-days window. The test substance can therefore not considered to be ready
biodegradable.
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