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EC number: 297-474-6 | CAS number: 93572-43-1 A complex combination of hydrocarbons obtained by refining of crude oil. It consists predominantly of aromatics, naphthenics and paraffinics and produces a finished oil with a viscosity of 120 SUS at 100°F (23cSt at 40°C).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: No data
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary study report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS pag 45-46
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Undiluted API 83-12 (cas 64742-53-6) was applied at doses of 200, 1000 and 2000 mg/kg/day to the shorn dorsal skin of groups of five male and five female rabbits. The test material was applied to the skin 3 times each week for 4 weeks (12 applications total). The applied material was covered with an occlusive dressing for 6 hours, which was then removed and the skin was wiped with a dry gauze to remove any residual material. A group of five rabbits of each sex served as sham controls.
The test skin site of each animal was examined and scored for irritation prior to each application of test material.
Mortality and moribundity checks were performed twice daily and body weights were recorded weekly.
At termination, blood samples were taken for a range of hematological and clinical chemical measurements. Urine samples were also collected and frozen for possible future examination.
A complete gross necropsy was performed on all animals.
Major organs were weighed and tissues were processed for subsequent histopathological examination - GLP compliance:
- not specified
Test material
- Reference substance name:
- Distillates (petroleum), hydrotreated light naphthenic
- EC Number:
- 265-156-6
- EC Name:
- Distillates (petroleum), hydrotreated light naphthenic
- Cas Number:
- 64742-53-6
- IUPAC Name:
- 64742-53-6
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- 6 hours each day, 3 times each week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200, 1000, 2000 mg/Kg
Basis:
no data
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Basis for effect level:
- other: Result are explained in "Any other information incl tables"
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No deaths occurred during the study. Skin irritation occurred to varying degrees in all animals treated with API 83-12. There was moderate irritation in the high dose males and females. In the mid dose group moderate irritation occurred in the females and slight irritation in the males. In the low dose group minimal irritation occurred in both sexes. The overall mean irritation scores were:
Dose level (mg/kg) | Males | Females |
Control | 0 | 0 |
200 | 0.1 | 0.4 |
1000 | 2.0 | 2.2 |
2000 | 2.6 | 3.1 |
Soft stool was also observed in several animals but this also occurred in a control male was not considered to be dose related. All high dose females appeared thin and this was considered to be treatment related. Body weight gains were reduced in the high dose males and females and in the mid dose females when compared to their respective controls. Overall weight changes (kg) are shown in the following table:
Dose level (mg/kg) | Males | Females |
Contrl | +0.5 | +0.3 |
200 | +0.3 | +0.4 |
1000 | +0.3 | +0.0 (*) |
2000 | +0.1 (*) | -0.2 (*) |
* statistically significant (p ≤ 0.05)
Clinical chemical and hematological values were considered to be unaffected by treatment. A low value for white cell count in the low dose female group was considered incidental since the value was within a normal range and was not a dose-related effect. Although there were some organ weight differences, they were considered incidental to treatment. The exception was for the absolute testis weights, which were lower in the high dose males and the relative weights of the right testis which were also lower than controls. At gross necropsy, findings for the skin consisted of dry, scaly, rough, fissured, crusted and/or thickened skin. This was a common finding in all treatment groups. Histopathological examination revealed slight to moderate proliferative changes in the skin in all rabbits in the high dose group. These changes were accompanied by an increased granulopoeisis of the bone marrow. The testes of 3 of the 5 males in the high dose group had bilateral diffuse tubular hypoplasia accompanied by aspermatogenesis and atrophy of the accessory sex organs. There were no changes observed in either the testes or epididymes of the male rabbits in the mid or low dose groups. No other treatment-related histopathological changes were recorded.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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