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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-benzyl-2-(2-chloroethoxy)-N,N-dimethylethanaminium chloride
EC Number:
938-632-2
Molecular formula:
C13H21Cl2NO
IUPAC Name:
N-benzyl-2-(2-chloroethoxy)-N,N-dimethylethanaminium chloride
Test material form:
other: solution in ethanol

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
1 rabbit : 3 bandages = 3 min + 1 hour + 4 hours.
2 rabbits : 1 bandage per rabbit for 4 hours.
Observation period:
1 hour after and then 24, 48 and 72 hours.
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 72h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 72h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 72h
Score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The tested substance is not irritating to the skin according to CLP Regulation.