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EC number: 627-872-0 | CAS number: 1514-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LC50, Inhalation, 4 hours (rat) = 11726 ppm
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 August 2002 - 14 January 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD and US EPA test guidelines, and in compliance with GLP; on this basis the result is considered reliable without restriction.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Group 1: Target 25,000 ppm, Analytical 26,580 ppm, Nominal 29,400 ppm
Group 4: Target 5,000 ppm, Analytical 5,173 ppm, Nominal 6,220 ppm - No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 11 726 ppm
- Based on:
- test mat.
- 95% CL:
- 9 054 - 15 186
- Exp. duration:
- 4 h
- Mortality:
- 26,580 ppm: 10/10 died
5,173 ppm: 0/10 died - Clinical signs:
- other: During exposure, labored breathing or gasping was reported during the last hour of each exposure. Immediately following the exposures, clear or red nasal discharge, excessive salivation, labored breathing and mosit rales were observed. The severity and
- Body weight:
- All surviving animals gained weight (or did not lose weight) during both weeks of observation.
- Gross pathology:
- One or more rats from both exposure levels had red discoloration of the lungs. Fluid was present in the lungs of one male fromt he higher level exposure of 26,580 ppm. Microscopically, in the unscheduled deaths, the discoloration was due to vascular congestion which is commonly seen in rats not found dead or moribund rior to post mortem examination. The scattered red foci were agonal hemorrhages. All of the rats in the 26, 580 ppm group had bronchiolar lesions consisting of desquamated epithelium, bronchiolar/peribronchiolar acute/subacute inflammation and/or intraluminal debris; the severity of the findings ranged from slight to moderate. Alveolar/intralveolar macrophages (minimal to moderate) normally present in lungs, were most numerous in several of these rats. Other findings in the lungs ocurred sporadically and were not considered to be test substance related. these findings have been seen in rats of this strain and age used in similar studies conducted at this facility.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4-hr acute inhalation toxicity in rats was 11,726 ppm.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 83 900 mg/m³ air
- Quality of whole database:
- The key study, referred to above, was considered reliable without restriction; the overall database is therefore considered to be of acceptable quality.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An acute inhalation toxicity study was conducted (Huntingdon Life Sciences, 2004) to assess the toxicity of 2-Bromo-3,3,3-trifluoropropene following a single 4-hour exposure by the inhaled route. The study was performed according to OECD guideline 403 and US EPA OPPTS 870.1300, and in compliance with GLP.
Ten rats (5 rats per sex) were initially exposed at a target concentration of 25000 ppm (analytical concentration = 26580 ppm); a subsequent group of ten rats were exposed to a target concentration of 5000 ppm (analytical concentration = 5173 ppm). All animals exposed at 26580 ppm were found dead or were euthanized due to poor condition on the day after exposure. All animals exposed at 5173 ppm survived to the end of the 14-day post-exposure observation period.
The LC50 for 2-Bromo-3,3,3-trifluoropropene following a 4-hour inhalation exposure was determined to be 11726 ppm.
Note: Inhalation LC50= 11726 ppm = 83.9 mg/L (83,900 mg/m3) (assuming volume of 1 mole of gas = 24.45 at 25°C and 1 atm, and molecular weight = 174.947).
Acute toxicity testing was not performed by the oral or dermal exposure routes. On the basis that the substance has a boiling point close to (but slightly lower than) body temperature it was considered that oral administration could result in rapid evaporation or boiling of the substance shortly after ingestion which could cause physical damage to the test animals without giving a useful indication of any toxic (local or systemic) effects; the study was therefore waived on ethical grounds. It was considered that the substance would rapidly evaporate following dermal contact and as such it was considered that consistent test material concentrations could not be maintained during the typical dermal exposure period (24 hours). The test was therefore waived on scientific grounds.
Justification for selection of acute toxicity – inhalation endpoint
Selected study was conducted according to modern test guidelines (OECD and US EPA) and in compliance with GLP, so is considered reliable. A second (supporting) study was available, but only considered exposure over 30 minutes which is significantly less than the exposure duration for this endpoint.
Justification for classification or non-classification
No information regarding oral or dermal administration of the substance are available. Due to the physical nature of the substance (a highly volatile liquid) it is expected that no significant exposure will occur by either of these routes.
2-Bromo-3,3,3-trifluoropropene is a liquid at room temperature, boiling at approximately 34°C; it is anticipated that under any forseeable use conditions that inhaled exposure will involve the substance in a vapour state. The LC50 of 2-bromo-3,3,3-triflouoropropene is 83.9 mg/L; acute toxicity category 4 for vapours applies where the LC50 is 20 mg/L or lower; on this basis the substance does not meet the classification criteria for acute toxicity according to the CLP Regulation.
Exposure to 2-bromo-3,3,3-triflouropropene appears to induce temporary depression of the central nervous system (note decreased activity seen after exposure to the higher test concentration in Huntingdon Life Sciences study (2004), and temporary anaesthesia seen following the 30-minute exposure study (Lovelace, 1999). On the basis of this sub-lethal effect it is considered that a classification for Specific Target Organ Toxicity (Single Exposure), Category 3 should be applied. The appropriate hazard phrase is H336 "May cause drowsiness or dizziness".
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