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EC number: 601-495-1 | CAS number: 117829-74-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
in vitro: Skin: not corrosive, EpiDerm TM corrosivity test, BASF 2002 (61H0616/002182)
Eye: not corrosive, Het-CAM Test, BASF 2002 (60H0616/002183)
in vivo: Skin: not irritating, OECD 404, BASF 2002 (18H0616/002206)
Eye: not irritating, OECD 405, BASF 2002 (11H0616/002301)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin:
An in vitro study was done by BASF in 2002 (EpiDerm TM corrosivity test). The test substance was tested at a concentration of 100% for its skin irritating potential in an in vitro test with human skin culture (EpiDerm TM). The viability of the treated cells in % of the negative control was determined. In this in vitro test the test substance proved to be non corrosive following the criteria of the Annex VI of the Commission Directive 67/548/EEC but a skin irritating potential could not be exluded. Therefore a further study according to OECD Guideline 404 was done by BASF (2002). The unchanged test substance was administered onto the intact skin of two White New Zealand rabbits under semiocclusive conditions for 4 hours. Readings for skin irritation findings (i.e. erythema, edema) were done 1, 24, 48 and 72 h after removal of the patch. The only finding was slight erythema in both animals at the 1-h reading. Thereafter no findings were seen. Thus, the test substance is not irritating to the skin under the test conditions chosen.
Eye:
An in vitro study was done by BASF in 2002. The test substance was tested in vitro in the HET-CAM Test. Undiluted test substance and 10% test substance in doubly distilled water was tested with each 3 eggs. After application of the test substance on the chorion-allantois membrane of the eggs the time until appearance of hemorrhagia, lysis and coagulation was examined and the index of irritation calculated. The experiment with the undiluted test substance led to coagulation within 56.0-71.0 seconds which leads to a mean index of irritation of 7.1. The experiment with 10% test substance in doubly distilled water led to in irritation index of 0.0. Since the results of the test were equivocal an additional in vivo study was performed by BASF in 2002 according to OECD 405. In this study, two White New Zealand rabbits were used. The test substance was applied undiluted into the conjunctival sac of one eye of both animals. Readings for eye irritation findings were performed 1, 24, 48 and 72 h as well as 7 d after test substance application. At the 1-h reading both animals showed marked redness and chemosis (score 2) as well as slight discharge. At the 24-h reading marked redness was still seen in the treated eyes of both animals. In 1/2 animals slight chemosis (score 1) was observed. Slight redness of the conjunctivae (score 1) persisted in both animals until the 72-h reading but was reversible within 7 days. The test substance is assessed as being not irritating to the eyes of rabbits under the present test conditions.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for skin and eye irritation under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for skin and eye irritation under Regulation (EC) No. 1272/2008.
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