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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Available data is not sufficient to conclude the repeated dose toxicity of sulphapyridine.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Study duration:
- subacute
- Species:
- other: rats, mice and monkey
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is one sub-chronic study (H. B. VAN DYKE, et al.)conducted with sulfapyridine administered to 3 species (i.e. rats, mice and monkey). In the case of mice, mice were fed the Sherman No. 1 diet containing the drugs in concentrations of 1 and 2 %. Mean of total dose eaten by survivors: 0.814 g and 1.477 g at the dose of 1% and 2%, respectively. And groups of growing albino rats were fed diets containing 0.5 and 1 % of the drug for a period of 57 days. No additional information was revealed except that no deaths occurred. In the cases of monkey,the drug as the free acid was administered by stomach tube to monkeys in a daily dose of 0.4 g per kilo body weight. Six of 7 monkeys receiving sulfapyridine began to exhibit hematuria and albuminuria after a few days and at necropsy were found to be suffering from unilateral or bilateral hydroureter and hydronephrosis.
However, in the case of monkeys, the study will be given less weight as there is only dose level applied and no effects with dose-related trend were observed during the test.
In another study (H. A. WALKER, et al. 1940), groups of young rats (Long-Evans strain; 7 males and 7 females in each group) were fed diets containing 0.5 or 1.0 percent of the drug for a period of 50 days. During the test, no gross or microscopic changes which could be attributed to drug were found in the livers. The spleens of all animals were normal. Microscopically there was a reduction or disappearance of the germinal centers of the malpighian bodies with an accompanying loss of lymphocytes from the mantle and marginal zones. Differential white cell counts were made on all animals at the conclusion of the experiment and little or no difference in the blood picture among the animals.
As a supporting study investigated by JOHN A. KOLMER and ANNAM . RULE., of 16 mice given 0.160 g by intra abdominal injection immediately after inoculation, 6 hours later and thereafter twice daily for 5 days, 4 survived while the lives of 6 were prolonged 1 to 5 days beyond the survival of 4 untreated controls which succumbed in 24 to 72 hours after inoculation.
Available data is not sufficient to derive the NOAEL value under the experimental conditions and cannot provide the scientific details that can be obtained from well-conducted animal studies. Therefore, available data is not sufficient to conclude the repeated dose toxicity of sulphapyridine.
Justification for classification or non-classification
As no scientific design details can be provided during the studies and there is no strong and reliable evidence associating the repeated exposure to the substance with a consistent and identifiable toxic effects. According to CLP ( Regulation EC No. 1272/2008), the available data is inconclusive for classification of specific target organ toxicity.
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