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EC number: 700-408-5 | CAS number: 103429-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- PHYSICO-CHEMICAL PROPERTIES
- Vapour pressure: 2.58hPa at 25°C
- Water solubility: 58g/L at 20°C
- log Pow: 1.6 at 25°C
- pKa: no data
- Base or acid catalysis of test material: no data
- Stability of test material at room temperature: no data - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products:
pH 4.0 : two points (at the start and after 5 days)
pH 1.2, pH 7.0, and pH 9.0: six points for test duration (each pH and each temperature)
- Sampling method: 1 mL (transfer pipet) - Buffers:
- Buffer Solutions
- pH 1.2: 12.9 mL of 1 mol/L hydrochloric acid and 5.0 mL of 2 mol/L potassuim chloride were determined with purified water to 200 mL of a constant volume.
- pH 4.0: 18.0 mL of 0.1 mol/L sodium hydroxide and 100 mL of 0.1 mol/L potassium dihydrogen citrate were determined with purified water to 200 mL of a constant volume.
- pH 7.0: 148.15 mL of 0.1 mol/L sodium hydroxide and 250 mL of 0.1 mol/L potassium dihydrogen phosphate were determined with purified water to 500 mL of a constant volume.
- pH 9.0: 106.5 mL of 0.1 mol/L sodium hydroxide, 0.1 mol/L potassium chloride, and 250 mL of 0.1 mol/L boric acid were determined with purified water to 500 mL of a constant volume. - Estimation method (if used):
- Methods of Calculating Residual Percentage of Test Substance, Rate Constant of Hydrolysis, and Half-Life Period
(1) Method of Calculating Residual Percentage of Test Substance (pH 4.0)
The residual factor of the test substance in the test liquid was calculated on the basis of the following equation.
Residual percentage (%) = C/Ci × 100
Ci : Initial concentration (mg/L) of test substance in test liquid
C : Concentration (mg/L) of test substance in test liquid after five days
(2) Method of Calculating Rate Constant of Hydrolysis and Half-Life Period (pH 7.0, pH9.0, and pH1.2)
The logarithm (log C) of the concentration of the test solution at each time was plotted for time (t) to deteramine a regression equation.
The regression equation can be expressed as : log C=at + b
and slant (a) and intercept (b) were calculated from this equation.
Also, the rate constant of the hydrolysis of the test substance and the half-life period were calculated by using the following equations.
k = -2.303 × a
t1/2 = 0.693/k
k : Rate constant of hydrolysis
t1/2 : Half-life period
In addition, with regard to pH7.0 and pH9.0, the logarithm (log k) of the rate constant of the hydrolysis at each temperature was plotted for the reciprocal number (1/T) of the absolute temperature, and a regression equation was found with the method of least squares. The rate constant of the hydrolysis and the half-life period at a temperature of 25°C were extrapolated and determined by using the regression equation obtained from the method of least squares. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 10 mL-Glass test tube with ground-in plug (covered with an aluminum foil)
- Sterilisation method: 0.22µm filter
- Lighting: Under condition of light shielding
- Measures taken to avoid photolytic effects: no data
- Measures to exclude oxygen: no data
TEST MEDIUM
- Volume used/treatment: 10mL
- Kind and purity of water: purified water
- Renewal of test solution: no
- Identity and concentration of co-solvent: none
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Dissolved oxygen: no data - Duration:
- 11 h
- pH:
- 1.2
- Temp.:
- 37 °C
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 971 mg/L
- Duration:
- 238 h
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 90 h
- pH:
- 7
- Temp.:
- 70 °C
- Duration:
- 24 h
- pH:
- 7
- Temp.:
- 80 °C
- Duration:
- 10 h
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 h
- pH:
- 9
- Temp.:
- 60 °C
- Duration:
- 130 min
- pH:
- 9
- Temp.:
- 70 °C
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- % Recovery:
- ca. 96.6
- pH:
- 4
- Duration:
- ca. 5 d
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- >= 1 yr
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- ca. 15 200 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- ca. 157 h
- Details on results:
- The test substance was immersed in a test liquid with pH 4.0 at a temperature of 50±0.1°C for five days. After the five days, the residual percentage is 90% or more, and therefore the half-life period at a temperature of 25 °C is regarded as being a year or more.
TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
MAJOR TRANSFORMATION PRODUCTS: no data
INDICATION OF UNSTABLE TRANSFORMATION PRODUCTS: no
PATHWAYS OF HYDROLYSIS
- Description of pathways: no
- Figures of chemical structures attached: No - Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was immersed in a test liquid with pH 4.0 at a temperature of 50±0.1°C for five days. After the five days, the residual percentage is 90% or more, and the test substance is regarded as being stable. The half-lives have been extrapolated at 15200h at pH 7.0 and at 157h at pH 9.0.
Reference
Table1: Hydrolysis
Test liquid | Initial concentration (mg/L) | Concentration after five days (mg/L) | Residual percentage (%) | |
Measured value | Mean value | |||
pH 4.0 | 971 | 944 | 97.3 | 96.6 |
931 | 95.9 |
Table2: Rate constant and half-life period
Rate constant (Hour^-1) | Half-life period (Hour) | ||
pH7.0 | 60°C | 4.64×10^-3 | 149 |
60°C | 4.64×10^-3 | 149 | |
70°C | 1.17×10^-2 | 59.2 | |
70°C | 1.17×10^-2 | 59.2 | |
80°C | 4.23×10^-2 | 16.4 | |
80°C | 4.15×10^-2 | 16.7 | |
25°C (extrapolated value) | 4.57×10^-5 | 15200 | |
pH 9.0 | 50°C | 6.92×10^-2 | 10.0 |
50°C | 7.05×10^-2 | 9.83 | |
60°C | 2.23×10^-1 | 3.11 | |
60°C | 2.23×10 ^-1 | 3.10 | |
70°C | 4.93×10^-1 | 1.41 | |
70°C | 4.90×10^-1 | 1.41 | |
25°C (extrapolated value) | 4.41×10^-3 | 157 | |
pH 1.2 | 37°C | 7.31×10^-2 | 9.48 |
37°C | 7.25×10^-2 | 9.56 |
Description of key information
The test substance was immersed in a test liquid with pH 4.0 at a temperature of 50±0.1°C for five days. After the five days, the residual percentage is 90% or more, and the test substance is regarded as being stable. The half-lives have been extrapolated at 15200h at pH 7.0 and at 157h at pH 9.0.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 15 200 h
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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