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Reaction mass of (1R,4S,4aR,8R,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8S,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1R,4S,4aR,8S,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8R,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one
EC number: 700-770-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011-01-05 - 2011-01-13 (experimental phase)
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study provides some useful information about the properties of the test item. However it has been conducted only at a screening level. No specific reference to a guideline is given in the study report. However it is assumed that the study design has been based on the main principles of a corresponding relevant guideline and that the study did not follow the corresponding guideline in detail. The level of information collected/reported is limited. In addition the study has not been performed according to GLP. As a consequence the reliability ("evaluating the inherent quality of a test report or publication relating to preferably standardized methodology and the way the experimental procedure and results are described to give evidence of the clarity and plausibility of the findings"), relevance ("covering the extent to which data and tests are appropriate for a particular hazard identification or risk characterization") and adequacy ("defining the usefulness of data for hazard/risk assessment purposes") of the data ("data quality") are considered as limited and an overall reliability rating of 3 (= not reliable, according to the scoring system of Klimisch et al.) has been assigned.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single dermal administration in the Wistar strain rat, according to a general study plan of the test facility.
- GLP compliance:
- no
- Remarks:
- However, the study was conducted in a facility operating to Good Laboratory Practice within the UK national GLP monitoring programme. The analytical characterisation of the test material has been performed according to GLP.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of (1R,4S,4aR,8R,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8S,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1R,4S,4aR,8S,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8R,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one
- EC Number:
- 700-770-4
- Molecular formula:
- C12H14Cl2O2
- IUPAC Name:
- Reaction mass of (1R,4S,4aR,8R,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8S,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1R,4S,4aR,8S,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8R,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- semi-occluded dermal application of the test item to intact skin at a dose level of 2000 mg/kg bodyweight
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- A group of four animals (two males and two females) was given a single, 24-hour, semi-occluded dermal application of the test item to intact skin at a dose level of 2000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy.
- Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths.
- Clinical signs:
- other: Individual clinical observations and mortality data are given in Table 1. Individual dermal reactions are given in Table 2
- Gross pathology:
- Individual necropsy findings are given in Table 4
- Other findings:
- Individual clinical observations and mortality data are given in Table 1. Individual dermal reactions are given in Table 2.
There were no deaths. Red/brown staining around the snout was noted during the day of dosing. No other signs of systemic toxicity were noted. Very slight erythema and desquamation and/or small superficial scattered scabs were noted in the females. No signs of dermal irritation were noted in the males.
Individual bodyweights and weekly bodyweight changes are given in Table 3 and individual necropsy findings are given in Table 4.
Any other information on results incl. tables
Results:
Table 1: Individual Clinical Observations and Mortality Data
Effects Noted After Initiation of Exposure (Hours) | Effects Noted After Initiation of Exposure (Days) | ||||||||||||
Dose Level (mg/kg) | Animal Number and Sex | 1/2 | 1 | 2 | 4 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
2000 | 1-0 Male | NAD | Ss | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD |
2000 | 1-1 Male | Ss | Ss | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD |
2000 | 2-0 Female | NAD | Ss | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD |
2000 | 2-1 Female | NAD | Ss | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD | NAD |
NAD = No abnormalities detected
Ss = Red/brown staining around the snout
Table 2: Individual Dermal Reactions*
Effects Noted After Initiation of Exposure (Days) | ||||||||||
Dose Level mg/kg | Animal Number and Sex | Observation | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
2000 | 1-0 Male | Erythema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 1-0 Male | Oedema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 1-0 Male | Other | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 1-1 Male | Erythema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 1-1 Male | Oedema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 1-1 Male | Other | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 2-0 Female | Erythema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 2-0 Female | Oedema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 2-0 Female | Other | 0 | 0 | 0 | 0 | 0 | 0 | Ss | 0 |
2000 | 2-1 Female | Erythema | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
2000 | 2-1 Female | Oedema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 2-1 Female | Other | 0 | 0 | 0 | D | D | Ss | 0 | 0 |
0 = No reactions
* = Scoring performed according to Draize (see Appendix 1)
Ss = Small superficial scattered scabs
D = Desquamation
Table 3: Individual Bodyweights and Weekly Bodyweight Changes
Bodyweight (g) at Day | Bodyweight Change (g) | |||
Dose Level mg/kg | Animal Number and Sex | Day of Dosing | Day 8 | Day 0 to Day 8 |
2000 | 1-0 Male | 294 | 295 | 1 |
2000 | 1-1 Male | 296 | 302 | 6 |
2000 | 2-0 Female | 225 | 216 | -9 |
2000 | 2-1 Female | 240 | 238 | -2 |
Table 4: Individual Necropsy Findings
Dose Levelmg/kg | Animal Number and Sex | Time of Death | Macroscopic Observations |
2000 | 1-0 Male | Killed Day 8 | No abnormalities detected |
2000 | 1-1 Male | Killed Day 8 | No abnormalities detected |
2000 | 2-0 Female | Killed Day 8 | No abnormalities detected |
2000 | 2-1 Female | Killed Day 8 | No abnormalities detected |
For "Scale According to Draize", see the Appendix (attachment to this endpoint study record).
Applicant's summary and conclusion
- Interpretation of results:
- other: see Conclusions below
- Conclusions:
- This study provides some useful information about the properties of the test item. However it has been conducted only at a screening level. No specific reference to a guideline is given in the study report. However it is assumed that the study design has been based on the main principles of a corresponding relevant guideline and that the study did not follow the corresponding guideline in detail. The level of information collected/reported is limited. In addition the study has not been performed according to GLP.
As a consequence the reliability ("evaluating the inherent quality of a test report or publication relating to preferably standardized methodology and the way the experimental procedure and results are described to give evidence of the clarity and plausibility of the findings"), relevance ("covering the extent to which data and tests are appropriate for a particular hazard identification or risk characterization") and adequacy ("defining the usefulness of data for hazard/risk assessment purposes") of the data ("data quality") are considered as limited and an overall reliability rating of 3 (= not reliable, according to the scoring system of Klimisch et al.) has been assigned. - Executive summary:
According to the results of the screening level acute dermal toxicity test (rat), the approx. LD50 is >2000 mg/kg bw. No deaths were observed at 2000 mg/kg bw (the single dose tested).
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