Registration Dossier
Registration Dossier
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EC number: 214-160-6 | CAS number: 1103-38-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- insufficient information to animals, enviromental conditions and test substance
- GLP compliance:
- no
- Remarks:
- priot to GLP-introduction
- Test type:
- standard acute method
Test material
- Reference substance name:
- Barium bis[2-[(2-hydroxynaphthyl)azo]naphthalenesulphonate]
- EC Number:
- 214-160-6
- EC Name:
- Barium bis[2-[(2-hydroxynaphthyl)azo]naphthalenesulphonate]
- Cas Number:
- 1103-38-4
- Molecular formula:
- C20H14N2O4S.1/2Ba
- IUPAC Name:
- barium(2+) bis(2-[(1E)-2-(2-hydroxynaphthalen-1-yl)diazen-1-yl]naphthalene-1-sulfonate)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 5-6 weeks
- Weight (g) at study initiation: 113 male, 109 female
- Fasting period before study: 18h
- Housing: singly
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- VEHICLE (50 % PEG)
- Concentration in vehicle: 17 %
- Amount of vehicle (if gavage): 30 ml
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: no mortality occurred
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs
- Gross pathology:
- no findings
- Other findings:
- The faces were stained red throughout the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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