Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-608-3 | CAS number: 1333-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary source: review of published data on from a read across substance.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report, hydrogen fluoride.
- Author:
- European Chemicals Bureau
- Year:
- 2 001
- Bibliographic source:
- European Union Risk Assessment Report, Volume 8, Institute for Health and Consumer Protection, European Chemicals Bureau.
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The EU RAR summarises the findings of various published studies reporting the toxicokinetics of HF.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen fluoride
- EC Number:
- 231-634-8
- EC Name:
- Hydrogen fluoride
- Cas Number:
- 7664-39-3
- IUPAC Name:
- fluoride
- Details on test material:
- The EU RAR summarises the findings of various published studies reporting the toxicokinetics of HF.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: various species, including man
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral, inhalation, dermal
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- Various
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Various
- No. of animals per sex per dose / concentration:
- Various
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- No data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Hydrogen fluoride is absorbed into the body and will ionise (>99.99%) to form the hydrogen (hydronium) and fluoride ions under physiological conditions. The absorption of inorganic fluoride across mucous membranes is passive and is independent of the fluoride source.
Following inhalation exposure to HF, experiments in various species including man have demonstrated that the large majority of inhaled HF does not reach the lungs but is absorbed via the upper respiratory tract mucosa. Plasma fluoride levels are directly related to HF inhalation and peak at between 60-120 hours after the start of exposure.
Following dermal exposure to HF, absorption is of fluoride likely to be minimal expect in cases where the normal skin structure is compromised as a consequence of the corrosive effects of the substance.
The absorption of fluoride following oral administration of HF has not been investigated, but is likely to be rapidly absorbed. - Details on distribution in tissues:
- Absorbed fluoride is distributed primarily in the blood, 75% in the plasma and 25% associated with erythrocytes. Half of the plasma fluoride may be bound to organic molecules. Fluoride is rapidly distributed and is sequestered in the bones and teeth, where exchange with hydroxyl groups results in incorporation into the bone and tooth structure. Levels of fluoride in bones and teeth are directly correlated with exposure levels.
- Details on excretion:
- Fluoride is excreted rapidly as a consequence of glomerular filtration, with a plasma half-life of 2-9 hours. The half-life for skeletal fluoride in humans is reported to be 8-20 years.
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- Not relevant. HF is ionised under physiological conditions (99.99%) to form hydronium and fluoride ions and is not metabolised as such.
Any other information on results incl. tables
HF is rapidly absorbed following inhalation exposure, rapidly distributed and excreted. However sequestration/accumulation of fluoride occurs in bones and teeth.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): high bioaccumulation potential based on study results
HF is rapidly absorbed following inhalation exposure, rapidly distributed and excreted. However sequestration/accumulation of fluoride occurs in bones and teeth. - Executive summary:
HF is rapidly absorbed following inhalation exposure, rapidly distributed and excreted. However sequestration/accumulation of fluoride occurs in bones and teeth.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)