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EC number: 232-191-3 | CAS number: 7789-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Excess Dietary Iodine upon Rabbits, Hamsters, Rats and Swine.
- Author:
- R. Arrington, R. N. Taylor, Jr., C. H. Ammerman AndR. L. Shirley
- Year:
- 1 965
- Bibliographic source:
- Journal of Nutrition; vol. 87, no. 4, pg. 394-398; December 1, 1965
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Long-Evans rats were fed sodium iodide atvarying intervals of time after breeding. The effect on length of gestation, parturition time, lactation and survival of young was observed.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium iodide
- EC Number:
- 231-679-3
- EC Name:
- Sodium iodide
- Cas Number:
- 7681-82-5
- IUPAC Name:
- sodium iodide
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report):Sodium iodide
- Molecular formula (if other than submission substance):INa
- Molecular weight (if other than submission substance):149.89427
- Substance type:Inorganic
- Physical state:Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Housing:Animals were housed individually in wire cages. Prior to littering, rats were transferred to 3 X 3 mesh wire cages.
- Diet (e.g. ad libitum):Purina Laboratory Chow were provided ad libitum
- Water (e.g. ad libitum):Tap water was supplied ad libitum
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Diet as Purina Laboratory Chow
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- The sexually mature females were bred to normal males of the breed or strain.
Monogamous pairs of rats were mated.When breeding occurred, the time of first copulation was recorded and gestation subsequently calculated from this time to birth of the first young of the litter.Fourteen female rats which had been fed iodine and had produced but lost all young in one or more litters were subsequently re-bred after removal from dietary iodine.
- After successful mating each pregnant female was caged (how): Individually - Duration of treatment / exposure:
- 12 days
- Frequency of treatment:
- Daily
- Duration of test:
- From breeding to day 21 of suckling
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0,150 mg/kg bw (2500 ppm)
Basis:
- No. of animals per sex per dose:
- 27 females
- Control animals:
- yes, concurrent vehicle
Examinations
- Maternal examinations:
- Observations were made for length of parturition time and number of young born dead and those born live. Periodic observations were made through the lactation period for mothering instinct, evidence of lactation and survival of young.
- Fetal examinations:
- All surviving young from each female in the control and experimental groups were permitted to nurse through the normal suckling period.
- Statistics:
- The data was subjected to statistical analysis.Method used included ANOVA were based upon analysis of variance.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
Gestation time for rats was not affected ; however, prolonged parturition was observed in rats.No signs of the beginning of lactation were observed.
Effect levels (maternal animals)
- Dose descriptor:
- LOAEL
- Effect level:
- 150 other: mg/kg bw
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
An increased incidence of death in the neonates, with <10% of the young surviving for 3 days.
Weaning weight was significantly less than that of controls.Survival of the young and body weights at weaning were equal to those of controls.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The LOAEL value of orally administered sodium iodide in rats was determined to be 150 mg/kg bw resulted in incidence of death in the neonates, with <10% of the young surviving for 3 days.Weaning weight was significantly less than that of controls.
- Executive summary:
Study was conducted with Long-Evans rat todetermine the effects of excess iodine intake. Females were bred to normal males,sodium iodide was added to the diet during the latter portion of gestation and the females were permitted to litter normally.
The effect of the treatment on gestation period, lactation and survival of the young was observed. Gestation time for rats was not affected ; however, prolonged parturition was observed in rats. Female rats re-bred after removal from dietary iodine produced and nursed litters normally. Incidence of death in the neonates, with <10% of the young surviving for 3 days.Weaning weight was significantly less than that of controls.
Since LOAEL is150 mg/kg bw, it is regarded that there is no developmental toxicity at concentrations lower than150 mg/kg bw when administered orally.
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