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EC number: 230-638-7 | CAS number: 7237-83-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A 28-day repeated dose oral toxicity study in rats conducted according to OECD test guideline 407 demonstrated a NOAEL of 150 mg/kg body weight/day for systemic toxicity of tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate. A repeated dose 90-day oral toxicity study is proposed by the lead registrant, subject to approval of the Test Plan by ECHA.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 150 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
In a 28-day repeated oral toxicity study no signs of toxicity were found at dose levels of 50 and 150 mg/kg bw/day. At a dose level of 500 mg/kg bw/day the following signs of toxicity were observed: slight clinical findings, slightly decreased body weight gain and food consumption intermittently during the treatment period in male animals. Increased spleen, kidney and adrenal weight and slightly decreased heart and prostate weight were without associated histopathological finding. Histopathological changes were seen in the testis and epididymis. Epididymal spermatic granuloma(s) were seen in all males of this group and were associated with inflammatory edema, increased incidence and degree of interstitial mononuclear cell infiltrates, condensed luminal content, bilateral oligospermia and/or bilateral intraluminal cellular debris in the epididymis and with tubular dilation of the testes in the same dose group.
Due to gender-specific signs of toxicity at the high dose level, separate NO(A)ELs can be placed for male and female animals of this study.
Male animals:
Signs of toxicity observed in male animals at the dose level of 500 mg/kg bw/day were: slightly decreased body weight, food consumption and the above-mentioned histopathological findings in reproductive organs. As no signs of toxicity were observed in male animals at the dose levels of the low and mid dose groups, the dose level of 150 mg/kg bw/day marks the NOAEL for male animals in this study.
Female animals:
No signs of toxicity were observed in female animals at dose levels of 50, 150 or 500 mg/kg bw/day. Thus, the dose level of 500 mg/kg bw/day marks the NOAEL for female animals in this study.
Minimal diffuse epithelial hyperkeratosis of the nonglandular part of the stomach was noted in a proportion of females treated at 500 mg/kg bw/day and considered to be possibly related to a local irritant effect of the test item formulation when administered repeatedly by oral gavage and therefore not to be relevant for humans.
Repeated dose toxicity: via oral route - systemic effects (target organ) urogenital: epididymides; urogenital: testes
Justification for classification or non-classification
Specific Target Organ Toxicity – Repeated Exposure: The notifiable substance did not exhibit significant toxic effects arising from a repeated exposure at a dose level of 500 mg/kg/day in female animals and at dose level of 150 mg/kg/day in male animals. As a result, the substance does not meet the criteria for classification according to Regulation (EC) No 1272/2008, Annex I section 3.9.
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