Registration Dossier
Registration Dossier
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EC number: 203-305-9 | CAS number: 105-53-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid. Adopted according to OECD SIDS (public available peer reviewed source).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
- Reference Type:
- publication
- Title:
- Range finding toxicity data. (List VII).
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani US, Striegel JA and Nycum JS.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc., 30:470-476.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to 24-hour cuff method of Draize et al. 1944
- Principles of method if other than guideline:
- The LD50 was determined by a method closely akin to the one-day cuff method of Draize et al. (1944) using groups of 4 male albino New Zealand rabbits. The fur was removed by clipping and the dose was retained beneath an impervious plastic film (i.e. occlusive). The animals were immobilized/exposed for 24 hours. Afterwards, the film was removed and the animals were observed for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Diethyl malonate
- EC Number:
- 203-305-9
- EC Name:
- Diethyl malonate
- Cas Number:
- 105-53-3
- Molecular formula:
- C7H12O4
- IUPAC Name:
- diethyl malonate
- Test material form:
- liquid
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- No. of animals per sex per dose:
- 4 per dose
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 mL/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 960 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- It can be concluded based on the study results that the acute dermal toxicity is > 16960 mg/kg bw and thus far above the limit for a classification according to GHS criteria.
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