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EC number: 222-423-1 | CAS number: 3467-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed research study, conducted prior to GLP and OECD guideline implementation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Company guideline similar to OECD 401
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-(2,5-dimethoxyphenyl)acetamide
- EC Number:
- 222-423-1
- EC Name:
- N-(2,5-dimethoxyphenyl)acetamide
- Cas Number:
- 3467-59-2
- Molecular formula:
- C10H13NO3
- IUPAC Name:
- N-(2,5-dimethoxyphenyl)acetamide
- Details on test material:
- - Name of test material (as cited in study report): Acetchinonbase
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG breeding colony
- Weight at study initiation: mean: 91 g (80 - 118)
- Fasting period before study: 16 hourrs
- Housing: plastic cages
- Diet: Altromin 1324, ad libitum
- Water: tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- 500, 630, 800, 900, 1000, 1600 mg/kg bw
as 10% suspension in sesame oil - No. of animals per sex per dose:
- 10 male per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation: daily; weighing: initially, after 7 days, after 14 days
- Necropsy of survivors and animals found dead performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 was determined by a Probit analysis (method according to Lindner and Weber); the confidence interval was calculated according to Cavalli-Sforza
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 962 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Remarks on result:
- other: no higher sensitivity in a preliminary test
- Mortality:
- 500 mg/kg: 0/10
630 mg/kg: 0/10
800 mg/kg: 0/10
900 mg/kg: 2/10
1000 mg/kg: 7/10
1600 mg/kg: 10/10 - Clinical signs:
- other: lethally intoxicated animals showed: disturbances of equilibrium, lateral and prone position, reddish eye discharge
- Gross pathology:
- no abnormal findings
- Other findings:
- no other findings
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50: 962 mg/kg bw
- Executive summary:
The acute oral toxicity of the test item was determined by application of doses of 500, 630, 800, 900, 1000 and 1600 mg/Kg bw as a 10% suspension in sesame oil to male Wistar-rats. 10 animlas per dose were used. Two animlas died at a dose of 900 mg/kg bw., 7 animals at 1000 mg/kg and ten at 1600 mg/kg bw. LD50 was determined by Probit-Analyse as 962 (918 - 1008) mg/kg bw.
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