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Diss Factsheets
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EC number: 217-752-2 | CAS number: 1948-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Remarks:
- aquatic organisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from HSDB and PubChem authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Environmental bioconcentration factor of the test substance in aquatic organisms was estimated using a log Kow and a regression-derived equation.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Aquatic organisms
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 2.94 - Type:
- BCF
- Value:
- 24 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- other: BCF value of test chemical was estimated using a log Kow and a regression-derived equation.
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The estimated BCF (bioaccumulation factor) of test chemical in aquatic organisms was determined to be 24 dimensionless.
- Executive summary:
The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
Reference
According to classification scheme, the BCF value of test chemical suggests that the potential for bioconcentration in aquatic organisms is low.
Description of key information
The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 24 dimensionless
Additional information
Experimental studies for test chemical and its structurally similar read across chemical have been reviewed for bioaccumulation endpoint and their results are summarized below.
First study was reveiwed from authoritative database ( HSDB, 2017) in this study the the bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
Another study was reviewed from authoritative database (J check) in this study the Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio. Recovery ratio : Test water : 1st concentration area : 90.1 %, 2nd concentration area : 79.6 %, Fish : 92.7 %, - Limit of detection : Fish : 0.
ppm And Nominal concentrations used in the study as - 1st Concentration area: 0.0001 mg/L, 2nd Concentration area : 0.00001 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 6.4 ppm(w/v), Rice fish (Oryzias latipes).Thus according to static Fish test the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period.Therefore it is concluded that this test chemical is nonbioaccumulative.
In last study the BCF value of test chemical was estimated is 57 dimensionless by using log Kow of 3.50 and regression derived equation and it is far less than 2000 so it is concluded that this chemical is non bioaccumulative.
By considering results of all the studies mentioned above it can be concluded that test chemical is non-bioaccumulative in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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