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EC number: 258-061-6 | CAS number: 52636-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
Based on the results of acute toxicity to fish study, the test substance had no toxic effect at the limit concentration of 100 mg/L on Zebrafish. The 96 h-NOEC value was determined to be 100 mg/L, the 96 h-LC50 and the 96 h-LOEC were determined to be higher than 100 mg/L.
Short-term toxicity to aquatic invertebrates
In a 48-hour acute toxicity test with Daphnia magna the 48 h-EC50 value and the 48 h-LOEC value were determined to be higher than 100 mg/L, and the 48 h-NOEC was determined as 100 mg/L. The results are based on the nominal test item concentrations.
Toxicity to aquatic algae
The toxicity of morpholinium sulphamate to algae was assessed according to OECD TG 201 and EU method C.3. The 72-h EC50 value based on growth rate and yield was determined to be greater than 100 mg/L. The 72-h NOEC based on growth rate and yield was determined to be greater than 100 mg/L.
Toxicity to microorganisms
For the assessment of toxicity to microorganism of morpholinium sulphamate several toxicity to microorganism studies conducted with morpholine, sulphamidic acid and morpholinium sulphamate were considered.
Morpholine
A test was performed in order to evaluate the effect of morpholine to the respiration of activated sludge obtained from domestic sewage treatment plant in accordance with OECD TG 209. The duration of the test was 30 min. Activated sludge was used as inoculum. It was taken from a domestic sewage treatment plant and washed before usage. The pH value of the activated sludge was adjusted to pH 7. The dry matter was determined as 5.0 g suspended solids/L The test was performed as limit test at nominal concentration of 1000 mg/L. 3,5-Dichlorophenole was used as reference item. The 30 min EC20 was determined to be greater than 1000 mg/L.
In addition a publication of Bringmann and Kühn the toxicity threshold of morpholine was assessed. Using analogous methods of the cell multiplication inhibition test, the toxicity threshold of 190 compounds including morpholine was determined for bacteria (Pseudomonas putida) and green algae (Scenedesmus quadricuada). Therefore cultures of pseudomonas putida were exposed in 4 different concentration queues of the substance. The dilution sequence was prepared as follows: In a first step 160 mL solution of the substance was prepared. Thereof 80 mL ware filled up to 100 mL with 5 mL Stock solution I and 5 mL stock solution II and 10 mL of bacteria suspension. After 16 h at 25 °C the extinction of the each sample was measured at Hg 436 nm with a coat thickness of 10 mm. The 16 h toxic threshold concentration based on growth inhibition was determined to be 310 mg/L.
Sulphamidic acid
A study was performed in order to evaluate the effect of sulphamidic acid to the respiration of activated sludge obtained from domestic sewage treatment plant in accordance with OECD TG 209. The activated sludge respiration test is a rapid screening method to identify substances which may adversely affect aerobic microorganisms. Duration of the test was three hours. Activated sludge was used as inoculum. It was taken from a domestic sewage treatment plant and washed before usage. The dry matter was determined as 4.77 g suspended solids/L, giving a concentration of 1.6 g suspended solids/L in the test. The study was performed with the nominal concentration of 60; 82, 110, 148 and 200 mg/L. 3,5-Dichlorophenole was used as reference item. The 3 h EC50 was determined to be greater than 200 mg/L.
Conclusion
No study was available for morpholinium sulphamate. Morpholinium sulpahamte is an organic ionic compound which dissociate in water into the corresponding cation morpholine and the corresponding anion sulphamidic acid. The EC50 of sulphamidic acid (200 mg/L) was regarded as worst case for morpholinium sulphamate.
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