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EC number: 687-538-5 | CAS number: 18423-20-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane nitrate
- EC Number:
- 687-538-5
- Cas Number:
- 18423-20-6
- Molecular formula:
- C6H13N5O3
- IUPAC Name:
- 3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Health status : Specific Pathogen Free (SPF)
Rationale for selection of species / strain :Rats are a suitable rodent species, acceptable to regulatory authorities as indicators of potential hazards, and for which extensive background data are available. Both sexes are dosed to establish that animals of one sex are not markedly more sensitive to the test substance
Total number of animals: 14 animals (10 –5 males and 5 females– used in the study and 4 spare animals)
Age of the animals on arrival: 8-week-old rats / 8 semanas
Animals per cage: At least 2
Bedding material: Capsumlab Lecho_10
Change of cages: At least once a week and when deemed necessary throughout the study period
Inclusion criteria on arrival:Veterinary inspection
Acclimatisation period: 7 days
Animal identificationl: Digit ink marks
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- Approximately 24 hours before the test, fur was removed from the dorsal area of the trunk of the animals by shaving. Care was taken to avoid abrading the skin, which could alter its permeability.The required volume of test item was spread on a sterile gauze patch (which does not exceed 10% of the total body surface area*) and was held in contact with the skin with a semi-occlusive bandage and a suitable dressing.
Animals were trained to wear the suitable dressing during the acclimatisation period. - Duration of exposure:
- Exposure period: 24h
- Doses:
- Single dose (2000 mg/kg). Dose selected according to the OECD guideline nº 402.
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No test item-related mortality was recorded during the study period in any of the males or females administered topically with a dose of 2,000 mg/kg.
- Clinical signs:
- other: All animals showed a normal behaviour and no systemic toxic signs were recorded throughout the whole 14- day observation period. The only local reaction associated with the test item application was that, immediately after patch removal, the skin from the
- Other findings:
- Neither macroscopic findings nor morphological changes were observed in the evaluated organs at necropsy
with the exception of the test item treated skin, which had a yellowish colour and was collected together with
normal untreated skin from the back. Both samples from each animal were preserved in fixative medium for
further analysis upon sponsor request.
Applicant's summary and conclusion
- Interpretation of results:
- other: GHS criteria for classes 1,2,3 and 4 not met
- Conclusions:
- Taking into account the results obtained in the current study, it is concluded that, under the assayed
experimental conditions and according to the OECD guideline for Testing of Chemicals Nº 402, the dermal
LD50 for the test item Hexamine Nitrate is established to be > 2000 mg/kg body weight. However, it is
important to point out that a 24h-exposure to this test item resulted in an intense yellow staining of the skin at
the area of administration.
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