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Diss Factsheets
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EC number: 470-720-1 | CAS number: 189253-72-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: assessment
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According REACH technical guidance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Evaluation of the available physico-chemical and toxicological data with the aim to describe toxicokinetic behaviour.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 470-720-1
- EC Name:
- -
- Cas Number:
- 189253-72-3
- Molecular formula:
- C10H25N3O
- IUPAC Name:
- N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine
- Details on test material:
- Not applicable. Acronym for the substance name is APMODAN.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: review of literature and data
- Strain:
- other: review of literature and data
- Sex:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Substance is highly soluble in water so it is to be expected that the oral bioavailability, and thus the systemic exposure is high.
- Type:
- distribution
- Results:
- Distribution of the hydrophilic APMODAN will be limited to total body water. Therefore a volume of distribution of about 0.7 /kg is expected.
- Type:
- metabolism
- Results:
- After absorption, substance may be excreted unchanged in urine.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Uptake via inhalation make take place based on the vapour pressure. Since the bioavailability of dermal applied compounds can assumed to be zero for substances with a log Pow below -1 and over 5 or a relative molecular mass over 700 (2), it is not to be expected that APMODAN will be absorbed through the skin.
- Details on distribution in tissues:
- The plasma protein binding is expected to be low. Accumulation in fatty tissues is not anticipated.
- Details on excretion:
- Metabolism may occur via dealkylation of the tertiary nitrogen's. Direct glucuronidation and sulfatation at the nitrogen group can be expected. Extensive cleavage of the ether bond is anticipated followed by rapid sulfatation of glucuronidation of the resulting molecules.
The resulting metabolites will be excreted via bile and/or urine.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results not expected to be excreted in breast milk
Based on the expected kinetic behavior in the body, as described above, APMODAN will show a relatively high absorption after oral administration, mainly because of its high water solubility. Uptake via inhalation make take place. If absorption occurs, APMODAN can be excreted unchanged or be extensively metabolized in the liver and rapidly excreted via bile and/or urine. Therefore, accumulation in the body during prolonged exposure will be very low. - Executive summary:
Based on the expected kinetic behavior in the body, APMODAN will show a relatively high absorption after oral administration, mainly because of its high water solubility. Uptake via inhalation may take place. If absorption occurs, APMODAN can be excreted unchanged or be extensively metabolized in the liver and rapidly excreted via bile andlor urine. Therefore, accumulation in the body during prolonged exposure will be very low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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