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Diss Factsheets
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EC number: 203-714-2 | CAS number: 109-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Methylal concentrations are not specified but can be derived from the graph representing the percentage mortality after 24 hours depending on the methylal concentration. Except their weights and origins, no other details on test animals and environmental conditions are specified.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Methylal
- IUPAC Name:
- Methylal
- Details on test material:
- - Name of test material (as cited in study report): Methylal
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 7 h
- Concentrations:
- Not specified but approximations can be derived from the graph representing the percentage mortality after 24 hours depending on the methylal concentration: 46, 53, 56, 57, 61, 65, 67 mg/L (see "Illustration" below).
- No. of animals per sex per dose:
- 10 (only males were used)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 57 000 mg/m³ air
- Based on:
- not specified
- Exp. duration:
- 7 h
Any other information on results incl. tables
When mortality occured, death were recorded during the exposure with 80% of the deaths within the last hour of exposure. With only one exception, allanimals survivng the 7-exposure period continued to live.
Within the first 15 minutes of exposure and at the approximate LC50, signs of respiratory tract irritation occured. Within one hour the mice became excited and progressively more ataxic. In the second hour they were unsteady to the point of being unable to remain upright, the fur was ruffled and theeyeswere irritated. Within the third hour, anaesthesia was reached and maintained until the end of the 7-hour exsposure. During anaesthesia, respiration became progressively more convulsive and irregular. When death did not occured during exposure, the mice almost invariably survied on removal from the chamber. Approximatively 2 hours o f breathing fresh air were required to restore the mice to full consciousness and coordinated control of their extremities.
LC50 value is approximatively 57 mg/L or 18354 ppm (see "Illustration" below).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50 value is approximatively 57 mg/L air (57000 mg/m3 air) or 18354 ppm. No classification required.
- Executive summary:
Mice in groups of 10 were exposed to different concentrations of methylal during a 7-hour period in three glass chambers (34 L volume). The approximated concentrations derived from the graph representing the percentage mortality after 24 hours depending on the methylal concentration were 46, 53, 56, 57, 61, 65, 67 mg/L. The death rate was recorded for 24 hours following exposure.
When mortality occured, death were recorded during the exposure with 80% of the deaths within the last hour of exposure. With only one exception, allanimals survivng the 7-hour exposure period continued to live.
Within the first 15 minutes of exposure and at the approximate LC50, signs of respiratory tract irritation occured. Within one hour the mice became excited and progressively more ataxic. In the second hour they were unsteady to the point of being unable to remain upright, the fur was ruffled and theeyeswere irritated. Within the third hour, anaesthesia was reached and maintained until the end of the 7-hour exsposure. During anaesthesia, respiration became progressively more convulsive and irregular. When death did not occured during exposure, the mice almost invariably survied on removal from the chamber. Approximatively 2 hours o f breathing fresh air were required to restore the mice to full consciousness and coordinated control of their extremities.
LC50 value is approximatively 57 mg/L air (57000 mg/m3 air) or 18354 ppm.
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