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EC number: 268-596-7 | CAS number: 68130-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions (no purity stated)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from the aeration basin of the domestic sewage treatment plant in Lachen-Speyerdorf, Germany (2008-05-08)
- Preparation of inoculum for exposure: The sludge was aerated continually, washed with and re-suspended in mineral medium. - Duration of test (contact time):
- 29 d
- Initial conc.:
- 29.7 mg/L
- Based on:
- test mat.
- Initial conc.:
- 31.9 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium according to OECD guideline
- Test temperature: 22 ± 1°C
- Aeration of dilution water: Before adding test and reference item, all flasks were aerated for > 24 h with purified, CO2-free, moistened air.
- Suspended solids concentration: 25 mg/L
TEST SYSTEM
- Culturing apparatus: 2000 mL-SCHOTT-flasks containing 1500 mL
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: Aeration with purified, CO2-scribbed, moistened air. The scrubbing of carbon dioxide was achieved by bubbling the purified air through a flask containing 1.5-m-NaOH.
- Measuring equipment: TOC multi N/C 2100S, Analytik Jena for IC measurement
- Details of trap for CO2 and volatile organics if used: The emitted CO2 was trapped in 0.25-m-NaOH. Two scrubber containing 100 mL each were connected in series to the test vessels.
SAMPLING
- Sampling frequency: on day 0, 2, 4, 7, 9, 11, 14, 17, 23 and 29
- Sampling method: On day 28, 5 mL HCl 2-m were added to all flasks in order to end the test and to drive off dissolved CO2 into the absorber flasks. Analyses of the emitted CO2 were made by IC measurement of samples from the front scrubber flask. Sample volume was 1 mL. Each sample was measured at least in duplicate. On day 29 samples from both absorber bottles were taken.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes, 2 replicates
- Abiotic control: Yes, 1 replicate
- Toxicity control: Yes, 1 replicate - Reference substance:
- aniline
- Remarks:
- 26.8 mg/L
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 85.3
- Sampling time:
- 29 d
- Details on results:
- Within the 10-day time window the 60% level was passed. Therefore, the test substance is regarded as readily biodegradable.
- Results with reference substance:
- Degradation: 83.5% after 7 days, 60% pass level was reached.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Jan - 20 Feb 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study. For read-across, maximum reliability score is 2.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from the aeration tank of a municipal waste water treatment plant, ARA Werdhölzli, 8048 Zürich, Switzerland (22 January 2007)
- Pretreatment: The sludge was washed twice with tap water. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20.7 - 20.9 mg/L
- Based on:
- other: TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Aerobic mineral salts medium prepared with deionised water
- Test temperature: 22 ± 0.5 °C
- pH adjusted: Yes, the pH-value was checked at the beginning and at the end of the test and adjusted to pH 7.4 (± 0.2) with NaOH or HCL.
- Suspended solids concentration: 30 mg/L
- Continuous darkness: Yes, temperature-controlled dark room
TEST SYSTEM
- Culturing apparatus: 2500 mL closed glass bottle containing a total volume of test solution of 2000 mL
- Number of culture flasks/concentration: 2/concentration
- Method used to create aerobic conditions: Aerated with synthetic CO2-free air for a maximum test period of 28 days.
- Measuring equipment: Shimadzu 5050 TOC-Analyzer using the NPOC-mode for DOC-determination
- Details of trap for CO2: The air leaving the individual vessels was passed through gas-absorption bottles filled with NaOH.
SAMPLING
- Sampling frequency: on day 0, 1, 3, 8, 10, 14, 17, 21, 24 and 28
- Sampling method: Samples were centrifuged (15 min at 4500g) and acidified to pH<2. Prior to analysis the samples were sparged with CO2-free high purity air for 10 min to remove inorganic carbon.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 72
- Sampling time:
- 28 d
- Results with reference substance:
- The reference substance was degraded to 90.6% at day 14 and to 87.9% at day 28.
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
Table 1: Degradation (%) of reference substance, test substance, abiotic control and toxicity control
Day |
Reference 1 |
Reference 2 |
Reference Mean |
Test 1 |
Test 2 |
Test Mean |
Abiotoc control |
Toxicity control |
2 |
-0.1 |
-0.1 |
-0.1 |
1.5 |
2.0 |
1.7 |
0.2 |
1.3 |
4 |
56.0 |
45.3 |
50.6 |
24.6 |
21.4 |
23.0 |
0.2 |
41.8 |
7 |
86.5 |
80.5 |
83.5 |
45.0 |
51.9 |
48.5 |
0.5 |
65.9 |
9 |
89.8 |
82.5 |
86.2 |
57.9 |
56.2 |
57.0 |
-0.2 |
70.4 |
11 |
89.5 |
89.2 |
89.4 |
64.0 |
61.2 |
62.6 |
-0.7 |
74.4 |
14 |
88.9 |
91.0 |
89.9 |
67.9 |
63.8 |
65.8 |
0.3 |
80.4 |
17 |
88.4 |
86.5 |
87.4 |
74.8 |
65.8 |
70.3 |
-0.7 |
77.2 |
23 |
90.1 |
88.1 |
89.1 |
79.7 |
77.1 |
78.4 |
-2.5 |
84.3 |
29 |
89.3 |
90.6 |
89.9 |
84.1 |
86.4 |
85.3 |
-1.1 |
87.9 |
The test substance is readily biodegradable under conditions tested. The biodegradation was > 60% after 28 days and the
10 -day-window was fulfilled, because the biodegradation reached 61% at the end of the 10 -day-window.
Table 1: Percentage biodegradation (mean of two replicates) of test and reference substance
Day |
Test substance (% degradation) |
Reference substance (% degradation) |
0 |
0.0 |
0.0 |
1 |
1.9 |
11.2 |
3 |
4.7 |
48.8 |
8 |
39.1 |
75.1 |
10 |
48.5 |
78.2 |
14 |
61.7 |
90.6 |
17 |
67.7 |
90.1 |
21 |
74.7 |
88.1 |
24 |
72.8 |
88.4 |
28 |
72.0 |
87.9 |
Description of key information
No relevant studies are available for decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane. Ready biodegradability studies are available for closely related structural analogues (CAS 11138-60-6 and CAS 78-16-0).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Two studies, investigating the ready biodegradability of closely related structural analogues are available:
The first study was conducted in accordance with OECD Guideline 301B (CO2 Evolution Test). Domestic activated sludge (non adapted) was used as inoculum and a mean degradation of 72% after 28 days was observed. The 60% pass level at the 10-day-window was reached therefore the test substance can be classified as readily biodegradable according to OECD criteria.
The second study was also conducted in accordance with OECD Guideline 301B (CO2 Evolution Test). Domestic activated sludge (non adapted) was used as inoculum and a mean degradation of 85.3% after 28 days was observed. The 60% pass level at the 10-day-window was reached therefore the test substance can be classified as readily biodegradable according to OECD criteria.
A report justifying the read-across approach is included in IUCLID Chapter 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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