Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 469-110-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This analogue substance was found through a quick and dirty search on similarity using the OECD QSAR toolbox. Estimated logPow values via KOWWIN v1.67 (EPIWEB 4.0) show very similar values above 10. Furthermore, physicochemical properties like melting point, boiling point and water solubility are very similar. Based on the points above and the fact that this analogue is probably worst case for bioconcentration than the registered substance (lower MW and therefore an expected higher bioavailability), it is deemed appropriate to use the bioconcentration data of this analogue to evaluate the bioaccumulation potential of the registered substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Bioconcentration test - unspecified
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
IUCLID data set ESIS:
- Melting point ca 140 ºC (unspecified method)
- Boiling point > 200 ºC or > 300 ºC (unspecified method)
- Insoluble in water (unspecified method)
- density ca 0.94 (unspecified method)
QSAR KOWWIN v1.67: logKow = 13.98
QSAR BCFBAF v3.00: estimated BCF = 5.048 L/kg wwt
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Lipid content 3.9%
Test conditions
- Details on test conditions:
- Test period: 6 weeks
Standard type test equipment
Two concentration sets: 0.083 mg/L and 0.830 mg/L
Results and discussion
Lipid content
- Lipid content:
- 3.9 %
- Time point:
- other: no information
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- < 6.2
- Basis:
- not specified
- Remarks on result:
- other: Conc.in environment / dose:0.083 mg/L
- Type:
- BCF
- Value:
- < 0.7
- Basis:
- not specified
- Remarks on result:
- other: Conc.in environment / dose:0.830 mg/L
Any other information on results incl. tables
The data of physico-chemical properties like melting point, boiling point, density and water solubility were compared between the analogue and the registered substance. All values were very similar.
The estimated logPow value via KOWWIN v1.67 (EPIWEB 4.0) of the analogue is 13.98. This value is very similar to the estimation for the registered substance (13.28) and both can be deemed to be higher than 10.
The estimated value of BCF via BCFBAF v3.00 of the analogue was very comparable with the estimated value of the registered substance (see 5.3.1 QSAR).
Based on the points above and the fact that this analogue is probably worst case for bioconcentration than the registered substance (lower MW and thus expected higher bioavailability), it is deemed appropriate to use the bioconcentration data of this analogue to evaluate the bioaccumulation potential of the registered substance.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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