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EC number: 700-957-0 | CAS number: 1141852-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Jun - 07 Jul 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- 1,3-Propanediol, 2-methyl-, reaction products with ethenyltrimethoxysilane
- EC Number:
- 700-957-0
- Cas Number:
- 1141852-17-6
- Molecular formula:
- UVCB
- IUPAC Name:
- 1,3-Propanediol, 2-methyl-, reaction products with ethenyltrimethoxysilane
- Reference substance name:
- Reaction products of trimethoxy(vinyl)silane and 2-methylpropane-1,3-diol (2:5-6)
- IUPAC Name:
- Reaction products of trimethoxy(vinyl)silane and 2-methylpropane-1,3-diol (2:5-6)
- Details on test material:
- - Name of test material (as cited in study report): Y-15866
- Physical state: liquid
- Analytical purity: 72%
- Lot/batch No.: 3710-10
- Stability under test conditions: at room temperature
Constituent 1
Constituent 2
Method
- Target gene:
- Not applicable
Species / strain
- Species / strain / cell type:
- Chinese hamster lung fibroblasts (V79)
- Details on mammalian cell type (if applicable):
- - Type and identity of media: MEM (Biochrom, Berlin, Germany) with Fetal Bovine Serum Standard Quality (PAA Laboratories GmbH, Cölbe, Germany)
- Properly maintained: yes
- Metabolic activation:
- with and without
- Metabolic activation system:
- co-factor supplemented post-mitochondrial fraction (S9 mix), prepared from the livers of 8-12 weeks old male Wistar Hsd Cpb: WU rats induced with 80 mg/kg bw phenobarbital i.p. and ß-naphthoflavone p.o. each on three consecutive days
- Test concentrations with justification for top dose:
- Experiment I: 4 h treatment with and without S9 mix
Cytotoxicity testing: 2.4, 4.9, 9.8, 19.5, 39.1, 78.1, 156.3, 312.5, 625, 1250, 2500 and 6950 µg/mL
Chromosome aberration analysis: 156.3, 312.5, 2500 and 6950 µg/mL (with S9); 312.5, 1250, 2500 and 6950 µg/mL (without S9)
Experiment II: 4 h treatment with S9 mix and 18 h without S9 mix
Cytotoxicity testing: 19.5#, 39.1, 78.1, 156.3, 312.5, 625, 1250, 2500 and 6950 µg/mL (#this concentration was additionally analysed in the absence of S9)
Chromosome aberration analysis: 39.1, 625#, 1250, 2500 and 6950 µg/mL (#this concentration was additionally analysed in the presence of S9)
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- tetrahydrofuran (THF)
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: -S9: ethyl methanesulfonate (EMS), 1000 (Exp. I) and 600 (Exp. II) µg/mL; +S9: cyclophosphamide (CPA), 1.4 (Exp. I) and 1.0 (Exp. II) µg/mL
Results and discussion
Test results
- Species / strain:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Under the experimental conditions reported, the test substance did not induce structural chromosome aberrations in V79 cells (Chinese hamster cell line).
- Executive summary:
The test substance Y-15866 was assayed in an in vitro mammalian chromosome aberration test conducted in accordance with GLP and similar to OECD guideline 473. In two independent experiments, V79 Chinese hamster cells were treated with the test substance at concentrations up to 6950 µg/mL, with and without metabolic activation system (S9 mix). In the first experiment, continuous treatment with the test substance for 4 h followed by a 14 h-recovery period was performed. Since no clear cytotoxicity indicated by reduced mitotic indices or reduced cell numbers was observed up to the highest concentration, 6950 µg/mL was chosen as top treatment concentration in Experiment II. In this experiment, cells were analogously treated with the test substance in the presence of S9 (4 h + 14 h recovery period). In contrast, cells were continuously treated for a period of 18 h without recovery period in the absence of S9 mix. Since no dose-response relationship was observed for cytotoxic effects in both experiments, concentrations used for evaluation of chromosome aberrations were selected based on the highest non-cytotoxic concentration tested. Thus, concentrations chosen for chromosome analysis ranged from 156.3 to 6950 µg/mL in Experiment I and 39.1 to 6950 µg/mL in Experiment II. In both experiments, no biologically relevant increase in the number of cells carrying structural chromosome aberrations was observed after treatment with the test substance in the absence and presence of S9 mix. The positive control substances yielded the expected results. Under the conditions of this chromosome aberration assay, it was concluded that Y-15866 did not show clastogenic activity in V79 Chinese hamster cells.
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