Registration Dossier
Registration Dossier
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EC number: 237-198-5 | CAS number: 13684-56-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-05-18 to 2016-06-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- Pow
- Partition coefficient:
- 3 490
- Temp.:
- 23 °C
- pH:
- 4
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.5
- Temp.:
- 23 °C
- pH:
- 4
- Conclusions:
- Acceptable. Validation data has been presented. Purified substance (99.6%): LogPow 3.5 at pH4 by flask method
- Executive summary:
Test Guidelines: European Commission Council Regulation (EC) No 440/2008, Annex, Part A, method A.8.OECD Guideline 107, US EPA Product Properties Test Guideline OCSPP830.7550
The partition coefficient 1-octanol/water of Desmedipham (AE B038107), pure substance, at room temperature (mean 23°C) was determined according to the “shake flask method”described in European Commission Council Regulation (EC) No 440/2008, Annex, Part A, method A.8., OECD Guideline 107 and US EPA Product Properties Test Guideline OCSPP830.7550.
Due to the lack of stability above pH 7, the partition coefficient was determined at pH 4 only.
The concentration of Desmedipham, pure substance was determined by HPLC analysis.
The reversed phase HPLC method used was found to be valid.
The result of the experiments is shownin the following table:
Partition coefficient of Desmedipham, pure substance,at room temperature (mean: 23°C)
Pow log Pow pH 4 3490 3.5
Reference
The partition coefficient 1-octanol / water ofDesmedipham (AE B038107), pure substanceat room temperature (mean 23°C) wasdetermined according to the "shake flaskmethod"described in European Commission Council Regulation (EC) No 440/2008, Annex, Part A, method A.8., OECD Guideline 107and US EPA Product Properties Test Guideline OCSPP830.7550.The partition coefficient was determined at pH 4 only.The concentration of Desmedipham(AE B038107), pure substancewas determinedby HPLC analysis.The reversed phase HPLC method used was found to be valid.The result of the experiments is shown in the following table below
Description of key information
The partition coefficient at room temperature (mean 23°C) was determined according to the “shake flask method”
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.5
Additional information
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